Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I

• Format: eBook
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: 2-a]pyrazoles; 3-dihydropyrazolo; 3-dipolar cycloadditions; 4-halopyrazole; 4-oxadiazoles; 5-a]pyrimidine; 5-a]pyrimidines; aliphatic amine; alkylation; Alzheimer’s disease; amination; antagonist; anti-inflammatory agents; anti-pathogens agents; anticancer agents; antimicrobial; antimicrobial activity; antitumor scaffold; aromatic substitution; azomethine imines; biofilm; biological activity; bipyrazole; bis(pyrazol-1-yl)alkanes; Buchwald-Hartwig coupling; carboxylation; Chemistry; coinage metals; coordination polymer; copper-catalyzed azomethine imine-alkyne cycloaddition (CuAIAC); coumarin; crystal structure; CuI mediated coupling; cyclic voltammetry; C–H halogenation; C–H thiocyanation; dicarboxylic acids; electrooxidation; energetic salts; enzymatic inhibitory; Fe(III); functionalization; heterocyclic; high energy density material; Hirshfeld; homocoupling; hydrazone; in vitro antitubercular screening; inhibitor; insensitivity; luminol; M06-2x; Mathematics and Science; metallacycles; metal–organic frameworks; molecular docking; MRSA; N-aminopyrazolopyrrolopyridine dione; N-heterocyclic compounds; n/a; neurodegeneration; nitrated pyrazoles-based; N–N coupling; Organic chemistry; organic synthesis; oxalyl chloride; Parkinson’s disease; Pd(dba)2; photoluminescence; polynuclear; protein kinase inhibitors; pyrazolate; pyrazolate ligand; pyrazole; pyrazole nucleus; pyrazoles; pyrazolo; pyrazolopyridopyridazine dione; pyrazolyl-s-triazine; pyrazolyl-ureas; reactivity; Reference, Information and Interdisciplinary subjects; Research and information: general; S. epidermidis; self-assembly; silver; spiropyrazolinium compounds; Staphylococcus aureus; styrylpyrazoles; superbasic medium; synthesis; transition-metal catalysts; X-ray; X-ray diffraction; ynones

Pyrazoles and their reduced form, pyrazolines, are considered privileged scaffolds in medicinal chemistry, owing to their noteworthy biological activities, physicochemical properties and occurrence in many low-molecular-weight compounds present in several marketed drugs (e.g., Celebrex® and Viagra®)...