Thermodynamics and Relative Solubility Prediction of Polymorphic Systems

• Published in: Chemical Engineering in the Pharmaceutical Industry p. 1
• Main Authors: Abramov, Yuriy A, Pencheva, Klimentina
• Format: Book Chapter
• Language: English
• Published: Hoboken, NJ, USA John Wiley & Sons 2011; John Wiley & Sons, Inc
• Subjects: application to likely impact on drug solubility estimation ‐ and unknown, more stable form; Chemistry & Chemical Engineering; General References; Pharmaceuticals; Pharmaceuticals, Cosmetics & Toiletries; qualification/quantification of impact ‐ of form change on drug absorption; thermodynamics and relative solubility prediction ‐ of polymorphic systems

This chapter contains sections titled: Introduction Methods Results and Discussion Example 25.1 Prediction of Ideal Solubility Ratio Between Forms II and I of Acemetacin at 293K Based on the Assumptions A, B, and C and Regression Equation 25.13 Application to an Estimation of Likely Impact on Drug S...