Thermodynamics and Relative Solubility Prediction of Polymorphic Systems

• Published in: Chemical Engineering in the Pharmaceutical Industry p. 1
• Main Authors: Abramov, Yuriy A, Pencheva, Klimentina
• Format: Book Chapter
• Language: English
• Published: Hoboken, NJ, USA John Wiley & Sons 2011; John Wiley & Sons, Inc
• Subjects: application to likely impact on drug solubility estimation ‐ and unknown, more stable form; Chemistry & Chemical Engineering; General References; Pharmaceuticals; Pharmaceuticals, Cosmetics & Toiletries; qualification/quantification of impact ‐ of form change on drug absorption; thermodynamics and relative solubility prediction ‐ of polymorphic systems

This chapter contains sections titled: Introduction Methods Results and Discussion Example 25.1 Prediction of Ideal Solubility Ratio Between Forms II and I of Acemetacin at 293K Based on the Assumptions A, B, and C and Regression Equation 25.13 Application to an Estimation of Likely Impact on Drug S...

Table of Contents:

• 25.1 Introduction 25.2 Methods 25.3 Results and Discussion 25.4 Application to an Estimation of Likely Impact on Drug Solubility by Unknown More Stable Form 25.5 Conclusion 25.A Appendix 25.B Appendix Acknowledgments References