Thermodynamics and Relative Solubility Prediction of Polymorphic Systems

This chapter contains sections titled: Introduction Methods Results and Discussion Example 25.1 Prediction of Ideal Solubility Ratio Between Forms II and I of Acemetacin at 293K Based on the Assumptions A, B, and C and Regression Equation 25.13 Application to an Estimation of Likely Impact on Drug S...

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Published inChemical Engineering in the Pharmaceutical Industry p. 1
Main Authors Abramov, Yuriy A, Pencheva, Klimentina
Format Book Chapter
LanguageEnglish
Published Hoboken, NJ, USA John Wiley & Sons 2011
John Wiley & Sons, Inc
Subjects
application to likely impact on drug solubility estimation ‐ and unknown, more stable form
Chemistry & Chemical Engineering
General References
Pharmaceuticals
Pharmaceuticals, Cosmetics & Toiletries
qualification/quantification of impact ‐ of form change on drug absorption
thermodynamics and relative solubility prediction ‐ of polymorphic systems
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Abstract This chapter contains sections titled: Introduction Methods Results and Discussion Example 25.1 Prediction of Ideal Solubility Ratio Between Forms II and I of Acemetacin at 293K Based on the Assumptions A, B, and C and Regression Equation 25.13 Application to an Estimation of Likely Impact on Drug Solubility by Unknown More Stable Form Example 25.2 Estimation of a Likely Impact on Solubility by a New Form of Ritonavir Appendix Conclusion Appendix Acknowledgments References
AbstractList This chapter contains sections titled: Introduction Methods Results and Discussion Example 25.1 Prediction of Ideal Solubility Ratio Between Forms II and I of Acemetacin at 293K Based on the Assumptions A, B, and C and Regression Equation 25.13 Application to an Estimation of Likely Impact on Drug Solubility by Unknown More Stable Form Example 25.2 Estimation of a Likely Impact on Solubility by a New Form of Ritonavir Appendix Conclusion Appendix Acknowledgments References
Author Ende David J. Am
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  organization: Pfizer Global Research & Development, Pharmaceutical Sciences, Sandwich, Kent, UK
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Copyright © 2011 John Wiley & Sons, Inc.
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Snippet This chapter contains sections titled: Introduction Methods Results and Discussion Example 25.1 Prediction of Ideal Solubility Ratio Between Forms II and I of...
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StartPage 1
SubjectTerms application to likely impact on drug solubility estimation ‐ and unknown, more stable form
Chemistry & Chemical Engineering
General References
Pharmaceuticals
Pharmaceuticals, Cosmetics & Toiletries
qualification/quantification of impact ‐ of form change on drug absorption
thermodynamics and relative solubility prediction ‐ of polymorphic systems
TableOfContents 25.1 Introduction 25.2 Methods 25.3 Results and Discussion 25.4 Application to an Estimation of Likely Impact on Drug Solubility by Unknown More Stable Form 25.5 Conclusion 25.A Appendix 25.B Appendix Acknowledgments References
Title Thermodynamics and Relative Solubility Prediction of Polymorphic Systems
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