Crystallization Design and Scale-up

• Published in: Chemical Engineering in the Pharmaceutical Industry p. 1
• Main Authors: McKeown, Robert Rahn, Wertman, James T, Dell'Orco, Philip C
• Format: Book Chapter
• Language: English
• Published: Hoboken, NJ, USA John Wiley & Sons 2011; John Wiley & Sons, Inc
• Subjects: Chemistry & Chemical Engineering; crystallization design and scale‐up ‐ optimal cycle time estimation for crystallization, isolation and drying process; crystallization kinetics and process selection; crystallization mechanisms ‐ and their relationship to solute concentration; General References; Pharmaceuticals; Pharmaceuticals, Cosmetics & Toiletries

This chapter contains sections titled: Introduction Crystallization Design Objectives and Constraints Example 13.1 Particle Size Distribution Calculations Example 13.2 Estimation of Optimal Cycle Time for a Crystallization, Isolation, and Drying Process Solubility Assessment and Preliminary Solvent...

Table of Contents:

• 13.1 Introduction 13.2 Crystallization Design Objectives and Constraints 13.3 Solubility Assessment and Preliminary Solvent Selection 13.4 Crystallization Kinetics and Process Selection 13.5 Understanding Crystallization Rate Processes: The Application of Solubility and Kinetics Data to Crystallization Modes 13.6 Batch Crystallization Scale-up References