Crystallization Design and Scale-up

• Published in: Chemical Engineering in the Pharmaceutical Industry p. 1
• Main Authors: McKeown, Robert Rahn, Wertman, James T, Dell'Orco, Philip C
• Format: Book Chapter
• Language: English
• Published: Hoboken, NJ, USA John Wiley & Sons 2011; John Wiley & Sons, Inc
• Subjects: Chemistry & Chemical Engineering; crystallization design and scale‐up ‐ optimal cycle time estimation for crystallization, isolation and drying process; crystallization kinetics and process selection; crystallization mechanisms ‐ and their relationship to solute concentration; General References; Pharmaceuticals; Pharmaceuticals, Cosmetics & Toiletries
• DOI: 10.1002/9780470882221.ch13
• ISBN: 9780470426692; 0470426691

This chapter contains sections titled: Introduction Crystallization Design Objectives and Constraints Example 13.1 Particle Size Distribution Calculations Example 13.2 Estimation of Optimal Cycle Time for a Crystallization, Isolation, and Drying Process Solubility Assessment and Preliminary Solvent Selection Example 13.3 Using Solubility to Predict Yield and Purity Crystallization Kinetics and Process Selection Example 13.4 Estimation of Metastable Zone Width by Cooling and Nucleation Induction Time Methods Understanding Crystallization Rate Processes: The Application of Solubility and Kinetics Data to Crystallization Modes Example 13.5 Batch Crystallization Scale‐Up Example 13.6 Heat Transfer Area Example 13.7 Solution Cooling Example 13.8 Crystallization Mixing References