IgG4-related disease-Insight from internal medicine

• Published in: Stomato-pharyngology Vol. 31; no. 1; pp. 77 - 81
• Main Author: Masaki, Yasufumi
• Format: Journal Article
• Language: Japanese
• Published: Japan Society of Stomato-pharyngology 2018; 日本口腔・咽頭科学会
• Subjects: comprehensive diagnostic criteria; differential diagnosis; glucocorticoid; Mikulicz’s disease; rituximab; ミクリッツ病; リツキシマブ; 副腎皮質ステロイド; 包括診断基準; 鑑別診断
• ISSN: 0917-5105; 1884-4316
• DOI: 10.14821/stomatopharyngology.31.77

This review describes methods to diagnose and treat patients with IgG4-related disease. A diagnosis of IgG4-related disease is based on elevated serum IgG4 concentrations and an increased number of IgG4-positive plasma cells. Differentiating IgG4-related disease from other disorders, especially malignancy, is important. Consensus treatment in Japan consists of an initial dose of prednisolone 0.5mg-0.6mg/kg/day, followed by careful and gradual dose reduction. The cooperation of otolaryngologists and internists is important in the diagnosis and treatment of IgG4-related disease, because the concomitant occurrence head and neck lesions frequently occurs.