The Clinical Evaluation of Guided Tissue Regeneration Using Polylactic Acid Membrane
The purpose of this study was to assess the clinical efficacy of guided tissue regeneration (GTR) surgery using polylactic acid membrane. Twelve healthy patients with Class II furcation involvements or vertical defects, participated in this study. Probing pocket depth (PD) and clinical attachment le...
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| Published in | The Journal of Showa University Dental Society Vol. 22; no. 4; pp. 345 - 351 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Showa University Dental Society
31.12.2002
昭和大学・昭和歯学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0285-922X 2186-5396 |
| DOI | 10.11516/dentalmedres1981.22.345 |
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| Abstract | The purpose of this study was to assess the clinical efficacy of guided tissue regeneration (GTR) surgery using polylactic acid membrane. Twelve healthy patients with Class II furcation involvements or vertical defects, participated in this study. Probing pocket depth (PD) and clinical attachment level (CAL) measurements and dental radiographs were taken immediately before surgery and at 6 months after surgery. Mean PD was reduced from 6.5±2.3mm to 2.8±0.6mm, with a mean reduction of 3.8±1.9mm. Mean CAL was reduced from 7.5±2.1mm to 4.5±1.3mm, with a mean attachment gain of 3.1±1.8mm. Radiographic improvement in the defect area was observed in six out of 12 patients. No side effects were observed during the 6 months. This study suggests that GTR surgery using polylactic acid membrane might be useful for periodontal tissue regeneration therapy. |
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| AbstractList | The purpose of this study was to assess the clinical efficacy of guided tissue regeneration (GTR) surgery using polylactic acid membrane. Twelve healthy patients with Class II furcation involvements or vertical defects, participated in this study. Probing pocket depth (PD) and clinical attachment level (CAL) measurements and dental radiographs were taken immediately before surgery and at 6 months after surgery. Mean PD was reduced from 6.5±2.3mm to 2.8±0.6mm, with a mean reduction of 3.8±1.9mm. Mean CAL was reduced from 7.5±2.1mm to 4.5±1.3mm, with a mean attachment gain of 3.1±1.8mm. Radiographic improvement in the defect area was observed in six out of 12 patients. No side effects were observed during the 6 months. This study suggests that GTR surgery using polylactic acid membrane might be useful for periodontal tissue regeneration therapy. The purpose of this study was to assess the clinical efficacy of guided tissue regeneration (GTR) surgery using polylactic acid membrane.Twelve healthy patients with Class II furcation involvements or vertical defects, participated in this study. Probing pocket depth (PD) and clinical attachment level (CAL) measurements and dental radiographs were taken immediately before surgery and at 6 months after surgery.Mean PD was reduced from 6.5±2.3mm to 2.8±0.6mm, with a mean reduction of 3.8±1.9mm.Mean CAL was reduced from 7.5±2.1mm to 4.5±1.3mm, with a mean attachment gain of 3.1±1.8mm.Radiographic improvement in the defect area was observed in six out of 12 patients.No side effects were observed during the 6 months.This study suggests that GTR surgery using polylactic acid membrane might be useful for periodontal tissue regeneration therapy. ポリ乳酸メンブレンを用いた歯周組織再生誘導法 (GTR法) の臨床的有用性について検討を行った.歯周外科手術が必要な2壁性および3壁性の垂直性骨欠損 (7名), または2度の根分岐部病変 (5名) を有した12名の被験者に対し, ポリ乳酸メンブレンを用いたGTR法を行った.エックス線写真撮影ならびに臨床診査としてProbing pocket depth (PD), Clinical attachment level (CAL), Plaque index (PII), Gingival index (GI) の測定を術前および術後6か月目に行った.PDは術前平均6.5±2.2mmから術後6か月目に平均2.7±0.7mmへと変化し, 平均3.8±1.9mmの統計学的に有意な減少が認められた (p<0.05).CALは, 術前平均7.7±2.2mmから術後約6か月目に平均4.6±1.2mmへと変化し, 平均3.1±1.8mmの統計学的に有意な付着の獲得が認められた (p<0.05).またエックス線写真における骨欠損相当部の透過性の減少は, 12例中6例で認められた.なお全症例において副作用等は認められなかった.以上の結果より, ポリ乳酸メンブレンを用いたGTR法は, 臨床的な改善が著明であり, 有用な手術法であると考えられた. |
| Author | SUZUKI, Motoyuki HASEGAWA, Kohji SAKATA, Junichi OHAZAMA, Atsushi MIYAZAWA, Yasushi |
| Author_FL | 鈴木 基之 長谷川 紘司 坂田 純一 宮澤 康 大峡 淳 |
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| References | 9) Aukhil I, Iglhaut J : Periodontal ligament cell kinetics following experimental regeneration procedures. J Clin Periodontol, 15 : 374-382, 1998 6) Löe H and Silness J : Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontologica Scandinavica, 21 : 535-551, 1963 10) Tonetti MS, Pini-Prato G, Cortellini P : Periodontal regeneration of human intrabony defects. IV. Determinants of healing response. J Periodontol, 64 : 934-940, 1993 11) Demolon IA, Persson GR, Moncla BJ, Johnson RH, Ammons WF : Effects of antibiotic treatment on clinical conditions and bacterial growth with guided tissue regeneration. J Periodontol, 64 : 609-616, 1994 13) Becker W, Becker BE, Berg L, Prichard J, Caffesse R, Rosenberg E : New attachment after treatment with root isoration procedures. Report for treated class III and class II furcations and verticalosseous defects. J Periodontol Restor Dent, 8 : 8-23, 1988 5) Silness J and Löe H : Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinavica, 22 : 121-135, 1964 3) 山田 了, 山之内一也, 高橋敬人, 青木栄夫, 佐藤徹一郎, 石川達也 : 垂直性骨欠損部への組織再生誘導法に関する臨床応用について. 日歯周誌, 33 : 138-145. 1991 1) Lindhe J : Textbook of Clinical Periodontology 2nd ed. Copenhagen, 1989, Munksgaard, pp 450-476 12) Hugason A, Ravald N, Fornell J, Johard G, Teiwik A, Gottlow J : Treatment of class II furcation involvements humans with bioresorbable and nonresorbable guided tissue regeneration barriers. A randomized multi-center study. J Periodontol, 66 : 624-634, 1995 8) Karring T, Nyman S, Lindhe J, Sirirat M : Potential for root resorption during periodontal wound healing. J Clin Periodontol, 11 : 41-52, 1984 7) 大峡 淳, 坂田純一, 桜井千里, 畑山 純, 田辺健次, 出口勝敏, 小杉禎久, 宮沢 康, 小林 誠, 鈴木基之, 立川哲彦, 長谷川紘司 : Guided tissueregeneration法におけるexpanded Polytetrafiuoroethyleneメンブレンの露出について. 日歯保誌, 40 : 1213-1228. 1997 2) 瀬戸口尚志, 高良憲明, 松永 信, 中山清貴, 竹内敏郎, 田方義弘, 樋渡京子, 立石基高, 内田博文, 南 睦美, 上稲葉隆, 竹内 誠, 保坂 均, 末田 武, 稲垣幸司, 吉成伸夫, 五十子元, 西山 均, 石川和弘, 中島 徹, 野口俊英, 横田 誠 : EPTFEメンブレンを用いた組織再生誘導法の臨症効果について. 日歯周誌, 33 : 1032-1039, 1991 4) Axellson P : 臨床予防歯科の実践第1版. 東京, 1992, Eiko Corporation, pp 83-102 14) Lekovic B, Kenny EB, Kouacevic K, Carranza JA : Evaluation of guided tissue regeneration in class II furcation defects. J Periodontol, 60 : 694-698, 1989 |
| References_xml | – reference: 2) 瀬戸口尚志, 高良憲明, 松永 信, 中山清貴, 竹内敏郎, 田方義弘, 樋渡京子, 立石基高, 内田博文, 南 睦美, 上稲葉隆, 竹内 誠, 保坂 均, 末田 武, 稲垣幸司, 吉成伸夫, 五十子元, 西山 均, 石川和弘, 中島 徹, 野口俊英, 横田 誠 : EPTFEメンブレンを用いた組織再生誘導法の臨症効果について. 日歯周誌, 33 : 1032-1039, 1991 – reference: 14) Lekovic B, Kenny EB, Kouacevic K, Carranza JA : Evaluation of guided tissue regeneration in class II furcation defects. J Periodontol, 60 : 694-698, 1989 – reference: 6) Löe H and Silness J : Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontologica Scandinavica, 21 : 535-551, 1963 – reference: 8) Karring T, Nyman S, Lindhe J, Sirirat M : Potential for root resorption during periodontal wound healing. J Clin Periodontol, 11 : 41-52, 1984 – reference: 10) Tonetti MS, Pini-Prato G, Cortellini P : Periodontal regeneration of human intrabony defects. IV. Determinants of healing response. J Periodontol, 64 : 934-940, 1993 – reference: 4) Axellson P : 臨床予防歯科の実践第1版. 東京, 1992, Eiko Corporation, pp 83-102 – reference: 12) Hugason A, Ravald N, Fornell J, Johard G, Teiwik A, Gottlow J : Treatment of class II furcation involvements humans with bioresorbable and nonresorbable guided tissue regeneration barriers. A randomized multi-center study. J Periodontol, 66 : 624-634, 1995 – reference: 13) Becker W, Becker BE, Berg L, Prichard J, Caffesse R, Rosenberg E : New attachment after treatment with root isoration procedures. Report for treated class III and class II furcations and verticalosseous defects. J Periodontol Restor Dent, 8 : 8-23, 1988 – reference: 7) 大峡 淳, 坂田純一, 桜井千里, 畑山 純, 田辺健次, 出口勝敏, 小杉禎久, 宮沢 康, 小林 誠, 鈴木基之, 立川哲彦, 長谷川紘司 : Guided tissueregeneration法におけるexpanded Polytetrafiuoroethyleneメンブレンの露出について. 日歯保誌, 40 : 1213-1228. 1997 – reference: 11) Demolon IA, Persson GR, Moncla BJ, Johnson RH, Ammons WF : Effects of antibiotic treatment on clinical conditions and bacterial growth with guided tissue regeneration. J Periodontol, 64 : 609-616, 1994 – reference: 3) 山田 了, 山之内一也, 高橋敬人, 青木栄夫, 佐藤徹一郎, 石川達也 : 垂直性骨欠損部への組織再生誘導法に関する臨床応用について. 日歯周誌, 33 : 138-145. 1991 – reference: 9) Aukhil I, Iglhaut J : Periodontal ligament cell kinetics following experimental regeneration procedures. J Clin Periodontol, 15 : 374-382, 1998 – reference: 1) Lindhe J : Textbook of Clinical Periodontology 2nd ed. Copenhagen, 1989, Munksgaard, pp 450-476 – reference: 5) Silness J and Löe H : Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinavica, 22 : 121-135, 1964 |
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| Title | The Clinical Evaluation of Guided Tissue Regeneration Using Polylactic Acid Membrane |
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