Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores

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Bibliographic Details
Published inJournal of Clinical Oncology Vol. 35; pp. 2240 - 2250
Main Authors Dominique Stoppa-Lyonnet, Ali Amin Al Olama, Joan Brunet, Veronica Medici, Kim De Leeneer, D. Gareth Evans, Paolo Peterlongo, Lone Sunde, Jihyoun Lee, Laura Ottini, Virginia Valentini, Jacob Musinsky, Daniel Barrowdale, Christi J. van Asperen, Lucy Side, David E. Goldgar, Dieter Niederacher, Georgia Chenevix-Trench, Francesca Damiola, Rosa B. Barkardottir, Jennifer T. Loud, Thomas Conner, Giulia Cini, Ute Hamann, Joseph Vijai, Esther M. John, Jong Won Lee, Ros Eeles, Kathleen Claes, Rosemarie Davidson, Alex Teulé, Doris Steinemann, Pedro Pinto, Christoph Engel, Soo-Hwang Teo, Jan Hauke, Edith Olah, Miquel Angel Pujana, Shirley Hodgson, Uffe Birk Jensen, Adalgeir Arason, Susan M. Domchek, Tibor Vaszko, Ramunas Janavicius, Mark H. Greene, Eric Hahnen, Sarah M. Nielsen, Kenneth Offit, Stefania Tommasi, Amanda B. Spurdle, Giuseppe Damante, Rachel C. Jankowitz, Penny Soucy, Dezheng Huo, Esther Darder, Jeffrey N. Weitzel, Anne Lincoln, Min Hyuk Lee, Andrew K. Godwin, Fergus J. Couch, Heli Nevanlinna, Ines Zanna, Linda Steele, Debra Frost, Christian Sutter, Priyanka Sharma, Inge Søkilde Pedersen, Bernard Peissel, Manuel R. Teixeira, Laura Cortesi, Goska Leslie, Domenico Palli, Nick Orr, Gillian Mitchell, Sylvie Mazoyer, Yen Y. Tan, Karin Kast, Laure Barjhoux, Saundra S. Buys, Julian Adlard, Katherine L. Nathanson, Pragna Gaddam, Eunyoung Kang, Sofia Khan, Lesley McGuffog, Karoline Kuchenbaecker, Andreas Berger, Kristiina Aittomäki, Shan Wang-Gohrke, Irene L. Andrulis, Orland Diez, Zisun Kim, Mattias Van Heetvelde, Embrace, Olufunmilayo I. Olopade, Louise Izatt, Pedro Pérez Segura, Yuan Chun Ding, Lídia Feliubadaló, Piera Rizzolo
Format Journal Article
LanguageJapanese
Published American Society of Clinical Oncology (ASCO) 10.07.2017
Subjects
80 and over
Adult
Adult; Age Factors; Aged; Aged, 80 and over; Breast Neoplasms, Male; Case-Control Studies; Genetic Predisposition to Disease; Genetic Testing; Genome-Wide Association Study; Heterozygote; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prostatic Neoplasms; Risk Assessment; Genes, BRCA1; Genes, BRCA2; Multifactorial Inheritance; Mutation; Oncology; Cancer Research
Age Factors
Aged
Aged, 80 and over
BRCA1
BRCA2
Breast Neoplasms
Breast Neoplasms, Male
Breast Neoplasms, Male/genetics
Case-Control Studies
ddc:610
ddc:no
dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
EMBRACE
FUNCTIONAL VARIANTS
GEMO Study Collaborators
Genes
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease
Genetic Testing
Genetic Testing for Cancer
GENETIC-VARIANTS
GENOME-WIDE ASSOCIATION
Genome-Wide Association Study
HEBON
Heterozygote
Humans
IDENTIFICATION
KConFab Investigators
Male
Male/genetics
Middle Aged
Multifactorial Inheritance
Mutation
ORIGINAL REPORTS
OVERDIAGNOSIS
Polymorphism
Polymorphism, Single Nucleotide
Prostatic Neoplasms
Prostatic Neoplasms/genetics
Risk Assessment
Risk Assessment/methods
SDG 3 - Good Health and Well-being
Single Nucleotide
SUSCEPTIBILITY LOCI
Wessex Classification Subject Headings::Oncology. Pathology.::Genetics
Online AccessGet full text
ISSN0732-183X
1527-7755
DOI10.1200/jco.2016.69.4935

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Author Lídia Feliubadaló
Elisa Alducci
Lotte Nylandsted Krogh
Mattias Van Heetvelde
Rosemarie Davidson
Ines Zanna
Min Hyuk Lee
Anna Sara Navazio
Jackie Cook
Dezheng Huo
Inge Søkilde Pedersen
Sarah M. Nielsen
Jacob Musinsky
Carole Brewer
Angela Toss
Barbara Wappenschmidt
Kim De Leeneer
Alex Teulé
Heli Nevanlinna
Florentia Fostira
Miklós Kásler
Ramunas Janavicius
Anna Marie Mulligan
Andrew K. Godwin
Zisun Kim
Giulia Cini
D. Gareth Evans
Paolo Peterlongo
Dorothea Wand
Georgia Chenevix-Trench
Ana Osorio
Christian Sutter
Paolo Radice
Debra Frost
Domenico Palli
Mary Porteous
Karoline Kuchenbaecker
Bernd Dworniczak
Silvia Tognazzo
Kai-ren Ong
Henriette Roed Nielsen
Dieter Niederacher
Anne Lincoln
Vanesa García-Barberán
Johanna I. Kiiski
Fergus J. Couch
Valentina Silvestri
Tibor Vaszko
Andreas Berger
Jacques Simard
Giuseppe Damante
Rita K. Schmutzler
Nick Orr
Orland Diez
Christi J. van Asperen
Sung-Won Kim
Irene L. Andrulis
Judith Balmaña
Steve Ellis
Miguel de la Hoya
Jennifer T. Loud
Jihyoun Lee
Thomas Conner
Shan Wang-Gohrke
Kerstin Rhiem
Esther M. John
Melissa C
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Asociación Española Contra el Cáncer
University of Kansas. Cancer Center (Estados Unidos)
Instituto de Salud Carlos III
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SubjectTerms 80 and over
Adult
Adult; Age Factors; Aged; Aged, 80 and over; Breast Neoplasms, Male; Case-Control Studies; Genetic Predisposition to Disease; Genetic Testing; Genome-Wide Association Study; Heterozygote; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prostatic Neoplasms; Risk Assessment; Genes, BRCA1; Genes, BRCA2; Multifactorial Inheritance; Mutation; Oncology; Cancer Research
Age Factors
Aged
Aged, 80 and over
BRCA1
BRCA2
Breast Neoplasms
Breast Neoplasms, Male
Breast Neoplasms, Male/genetics
Case-Control Studies
ddc:610
ddc:no
dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
EMBRACE
FUNCTIONAL VARIANTS
GEMO Study Collaborators
Genes
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease
Genetic Testing
Genetic Testing for Cancer
GENETIC-VARIANTS
GENOME-WIDE ASSOCIATION
Genome-Wide Association Study
HEBON
Heterozygote
Humans
IDENTIFICATION
KConFab Investigators
Male
Male/genetics
Middle Aged
Multifactorial Inheritance
Mutation
ORIGINAL REPORTS
OVERDIAGNOSIS
Polymorphism
Polymorphism, Single Nucleotide
Prostatic Neoplasms
Prostatic Neoplasms/genetics
Risk Assessment
Risk Assessment/methods
SDG 3 - Good Health and Well-being
Single Nucleotide
SUSCEPTIBILITY LOCI
Wessex Classification Subject Headings::Oncology. Pathology.::Genetics
Title Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores
URI https://cir.nii.ac.jp/crid/1872273591458700672
Volume 35
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