Trends of ion channel researches

細胞膜においてイオンを多量に輸送し,それに伴って電気的信号を発生する(ので情報伝達にも関与する)膜貫通性蛋白であるイオンチャネルには,いくつかの種類がある.最近それらの多くの遺伝子がクローニングされ,これによってチャネルの重要な機能がどのような構造的基盤にもとづくのか明らかになるとともに,その遺伝子の突然変異がいくつかの先天性疾患の原因となっていることが明らかになった.更に最近,イオンチャネルは,他のチャネルやトランスポータに対するレギュレータとして働いたり,物理化学的環境因子に対する膜センサーとしても働く事例が多く見出され,多機能性蛋白としても注目されはじめている....

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Published inShinzo Vol. 31; no. 12; pp. 847 - 853
Main Author Okada, Yasunobu
Format Journal Article
LanguageJapanese
Published Japan Heart Foundation 15.12.1999
Subjects
ABCトランスポータ
イオンチャネル
バイオ分子センサー
細胞容積調節
Online AccessGet full text
ISSN0586-4488
2186-3016
DOI10.11281/shinzo1969.31.12_847

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Abstract 細胞膜においてイオンを多量に輸送し,それに伴って電気的信号を発生する(ので情報伝達にも関与する)膜貫通性蛋白であるイオンチャネルには,いくつかの種類がある.最近それらの多くの遺伝子がクローニングされ,これによってチャネルの重要な機能がどのような構造的基盤にもとづくのか明らかになるとともに,その遺伝子の突然変異がいくつかの先天性疾患の原因となっていることが明らかになった.更に最近,イオンチャネルは,他のチャネルやトランスポータに対するレギュレータとして働いたり,物理化学的環境因子に対する膜センサーとしても働く事例が多く見出され,多機能性蛋白としても注目されはじめている.
AbstractList 細胞膜においてイオンを多量に輸送し,それに伴って電気的信号を発生する(ので情報伝達にも関与する)膜貫通性蛋白であるイオンチャネルには,いくつかの種類がある.最近それらの多くの遺伝子がクローニングされ,これによってチャネルの重要な機能がどのような構造的基盤にもとづくのか明らかになるとともに,その遺伝子の突然変異がいくつかの先天性疾患の原因となっていることが明らかになった.更に最近,イオンチャネルは,他のチャネルやトランスポータに対するレギュレータとして働いたり,物理化学的環境因子に対する膜センサーとしても働く事例が多く見出され,多機能性蛋白としても注目されはじめている.
Author Okada, Yasunobu
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DocumentTitleAlternate 第32回志摩循環器カンファランス テーマ : イオンチャンネルと疾患 イオンチャネルに関する研究の動向
DocumentTitle_FL 第32回志摩循環器カンファランス テーマ : イオンチャンネルと疾患 イオンチャネルに関する研究の動向
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References 2) Hodgkin AL, Huxley AF : The components of membrane conductance in the giant axon of Loligo. J Physiol 1952 ; 116 : 473-496
34) Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D : The capsaicin receptor : A heat-activated ion channel in the pain pathway. Nature 1997 ; 389 : 816-824
7) Unwin N : Nicotinic acetylcholine receptor at 9A resolution. J Mol Biol 1993 ; 229 : 1101-1124
31) Reisin IL, Prat AG, Abraham EH, et al : The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel. J Biol Chem 1994 ; 269 : 20584-20591
9) Ohno K, Hutchingson DO, Milone M, et al : Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel open ings due to a mutation in the M 2 domain of the E subunit. Proc Nall Acad Sci USA 1995 ; 92 : 758-762
17) Goldstein SAN : A structural vignette common to voltage sensors and conduction pores : Canaliculi. Neuron 1996 ; 16 : 717-722
27) Egan M, Flotte T, Afione S, et al : Defective regulation of outwardly rectifying Cl- channels by protein kinase A corrected by insertion of CFTR. Nature 1992 ; 358 : 531-536
37) Okada Y : Volume expansion-sensing outward rectifier Cl channel : A fresh start to the molecular identity and volume sensor. Am J Physiol 1997 ; 273 : C 755-C 789
5) 岡田泰伸:チャネルとトランスポーターその構造・機能協関と疾病。チャネルとトランスポータ1その働きと病気。メジカルビュー社,!997,H5
26) Wang Z, Mitsuiye T, Rees SA, Noma A: Regulatory volume decrease of cardiac myocytes induced by p-adrenergic activation of the Cl- channel in guinea pig. J Gen Physiol 1997 ; 110 : 73-82
20) Hoshi T, Zagotta WN, Aldrich RW : Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 1990 ; 250 : 533-538
29) Schwiebert EK, Egan ME, Hwang TH , et al : CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Cell 1995 ; 81 : 1063-1073
36) Okada Y (ed.) : "Cell volume regulation : The molecular mechanism and volume sensing machinery." Elsevier, Amsterdam, 1998 : 1-214
12) Noda M, Shimizu S, Tanabe T, et al : Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence. Nature 1984 ; 312 : 121-127
30) Hazama A, Miwa A, Miyoshi T, Shimizu T, Okada Y : ATP release from swollen or CFTR-expressing epithelial cells. In, "Cell volume regulation : The molecular mechanism and volume sensing machinery" (ed Y. Okada). Elsevier, Amsterdam 1998 ; pp 93-98
8) Sine SM, Ohno K, Bouzat C, et al : Mutation of the acetylcholine receptor a subunit causes a slow-channel myasthenic syndrome by enhanc ing agonist binding affinity. Neuron 1995 ; 15 : 229-239
14) Kamb A, Iverson LE, Tanouye MA : Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel. Cell 1987 ; 50 : 405-413
25) James AF, Tominaga T, Okada Y, Tominaga M : Distribution of cAMP-activated chloride current and CFTR mRNA in the guinea pig heart. Circ Res 1996 ; 79 : 201-207
23) 岡田泰伸:Crチャネルの機能・構造と疾患.神経研究の進歩1998;42:263-278
32) Inagaki N, Gonoi T, Clement IV JP, et al : Reconstitution of IKATP An inward rectifier subunit plus the sulfonylurea receptor. Science 1995 ; 270 : 1166-1170
10) Steinlein OK, Mulley JC, Propping P, et al : A missense mutation in the neuronal nicotinic acetylcholine receptor a 4 subunit is associated with autosomal dominant nocturnal frontal lobe epithepsy. Nature Genetics 1995 ; 11 : 201-203
1) Hudgkin AL, Huxley AF : Current carried by sodium and potassium ions through the mem brane of the giant axon of Loligo. J Physiol 1952 ; 116 : 449-472
18) Ho K, Nichols CG, Lederer WJ , et al : Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature 1993 ; 362 : 31-38
33) Clement IV JP, Kubjilwar K, Gonzales G, et al : Association and stoichiometry of K (ATP) channel subunits. Neuron 1997 ; 88 : 827-838
35) Tominaga M, Caterina MJ, Malmberg AB, et al : The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 1998 ; 21 531-543
24) Hart P, Warth JD, Levesque PC, Collier ML, Geary Y, Horowitz B : Cystic fibrosis gene encodes a cAMP-dependent chloride channel ir heart. Proc Natl Aced Sci USA 1996 ; 93 :-6348
11) Shiang R, Ryan SG, Zhu Y-Z, Hahn AF, 0'Connell P, Wasmuth JJ : Mutations in the al subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekple xia. Nature Genetics 1993 ; 5 : 351-358
4) 岡田泰伸(編):パッチクランプ実験技術法.吉岡.吉岡 書店,1996,n85
21) 岡田泰伸:チャネル病.遺伝子医学1998;2:68-75
28) Stutts MJ, Canessa CM, Olsen JC, et al : CFTR as a cAMP-dependent regulator of sodium channels. Science 1995 ; 269, 847-850
13) Tanabe T, Takeshima H, Mikami A, et al : Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature 1987 ; 328 : 313-318
6) Noda M, Furutani Y, Takahashi H, et al : Cloning and sequence analysis of calf cDNA and human genomic DNA encoding a-subunit precursor of muscle acetylcholine receptor. Nature 1983 ; 305 : 818-823
15) Papazian DM, Schwarz TL, Tempel BL, Jan YN, Jan LY : Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila. Science 1987 ; 237 : 749-753
16) Doyle DA, Cabral JM, Pfuetzner RA , et al : The structure of the potassium channel Molecular basis of K+ conduction and selectivity. Science 1998 ; 280 : 69-77
19) Kubo Y, Baldwin TJ, Jan YN, Jan LY : Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature 1993 ; 362 : 127-133
38) Okada Y, Oiki S, Hazama A, Morishima S : Criteria for the molecular identification of the volume-sensitive outwardly rectifying Clchannel. J Gen Physiol 1998 ; 112 : 1-3
3) Neher E, Sakmann B : Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature 1976 ; 260 : 799-802
22) Riordan JR, Rommens JM, Kerem B, et al : Identification of the cystic fibrosis gene : cloning and characterization of complementary DNA. Science 1989 ; 245 : 1066-1073
References_xml – reference: 6) Noda M, Furutani Y, Takahashi H, et al : Cloning and sequence analysis of calf cDNA and human genomic DNA encoding a-subunit precursor of muscle acetylcholine receptor. Nature 1983 ; 305 : 818-823
– reference: 37) Okada Y : Volume expansion-sensing outward rectifier Cl channel : A fresh start to the molecular identity and volume sensor. Am J Physiol 1997 ; 273 : C 755-C 789
– reference: 4) 岡田泰伸(編):パッチクランプ実験技術法.吉岡.吉岡 書店,1996,n85
– reference: 7) Unwin N : Nicotinic acetylcholine receptor at 9A resolution. J Mol Biol 1993 ; 229 : 1101-1124
– reference: 26) Wang Z, Mitsuiye T, Rees SA, Noma A: Regulatory volume decrease of cardiac myocytes induced by p-adrenergic activation of the Cl- channel in guinea pig. J Gen Physiol 1997 ; 110 : 73-82
– reference: 35) Tominaga M, Caterina MJ, Malmberg AB, et al : The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 1998 ; 21 531-543
– reference: 28) Stutts MJ, Canessa CM, Olsen JC, et al : CFTR as a cAMP-dependent regulator of sodium channels. Science 1995 ; 269, 847-850
– reference: 9) Ohno K, Hutchingson DO, Milone M, et al : Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel open ings due to a mutation in the M 2 domain of the E subunit. Proc Nall Acad Sci USA 1995 ; 92 : 758-762
– reference: 27) Egan M, Flotte T, Afione S, et al : Defective regulation of outwardly rectifying Cl- channels by protein kinase A corrected by insertion of CFTR. Nature 1992 ; 358 : 531-536
– reference: 17) Goldstein SAN : A structural vignette common to voltage sensors and conduction pores : Canaliculi. Neuron 1996 ; 16 : 717-722
– reference: 31) Reisin IL, Prat AG, Abraham EH, et al : The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel. J Biol Chem 1994 ; 269 : 20584-20591
– reference: 32) Inagaki N, Gonoi T, Clement IV JP, et al : Reconstitution of IKATP An inward rectifier subunit plus the sulfonylurea receptor. Science 1995 ; 270 : 1166-1170
– reference: 22) Riordan JR, Rommens JM, Kerem B, et al : Identification of the cystic fibrosis gene : cloning and characterization of complementary DNA. Science 1989 ; 245 : 1066-1073
– reference: 8) Sine SM, Ohno K, Bouzat C, et al : Mutation of the acetylcholine receptor a subunit causes a slow-channel myasthenic syndrome by enhanc ing agonist binding affinity. Neuron 1995 ; 15 : 229-239
– reference: 18) Ho K, Nichols CG, Lederer WJ , et al : Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature 1993 ; 362 : 31-38
– reference: 29) Schwiebert EK, Egan ME, Hwang TH , et al : CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Cell 1995 ; 81 : 1063-1073
– reference: 33) Clement IV JP, Kubjilwar K, Gonzales G, et al : Association and stoichiometry of K (ATP) channel subunits. Neuron 1997 ; 88 : 827-838
– reference: 38) Okada Y, Oiki S, Hazama A, Morishima S : Criteria for the molecular identification of the volume-sensitive outwardly rectifying Clchannel. J Gen Physiol 1998 ; 112 : 1-3
– reference: 10) Steinlein OK, Mulley JC, Propping P, et al : A missense mutation in the neuronal nicotinic acetylcholine receptor a 4 subunit is associated with autosomal dominant nocturnal frontal lobe epithepsy. Nature Genetics 1995 ; 11 : 201-203
– reference: 21) 岡田泰伸:チャネル病.遺伝子医学1998;2:68-75
– reference: 25) James AF, Tominaga T, Okada Y, Tominaga M : Distribution of cAMP-activated chloride current and CFTR mRNA in the guinea pig heart. Circ Res 1996 ; 79 : 201-207
– reference: 34) Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D : The capsaicin receptor : A heat-activated ion channel in the pain pathway. Nature 1997 ; 389 : 816-824
– reference: 2) Hodgkin AL, Huxley AF : The components of membrane conductance in the giant axon of Loligo. J Physiol 1952 ; 116 : 473-496
– reference: 20) Hoshi T, Zagotta WN, Aldrich RW : Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 1990 ; 250 : 533-538
– reference: 30) Hazama A, Miwa A, Miyoshi T, Shimizu T, Okada Y : ATP release from swollen or CFTR-expressing epithelial cells. In, "Cell volume regulation : The molecular mechanism and volume sensing machinery" (ed Y. Okada). Elsevier, Amsterdam 1998 ; pp 93-98
– reference: 11) Shiang R, Ryan SG, Zhu Y-Z, Hahn AF, 0'Connell P, Wasmuth JJ : Mutations in the al subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekple xia. Nature Genetics 1993 ; 5 : 351-358
– reference: 12) Noda M, Shimizu S, Tanabe T, et al : Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence. Nature 1984 ; 312 : 121-127
– reference: 13) Tanabe T, Takeshima H, Mikami A, et al : Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature 1987 ; 328 : 313-318
– reference: 19) Kubo Y, Baldwin TJ, Jan YN, Jan LY : Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature 1993 ; 362 : 127-133
– reference: 24) Hart P, Warth JD, Levesque PC, Collier ML, Geary Y, Horowitz B : Cystic fibrosis gene encodes a cAMP-dependent chloride channel ir heart. Proc Natl Aced Sci USA 1996 ; 93 :-6348
– reference: 15) Papazian DM, Schwarz TL, Tempel BL, Jan YN, Jan LY : Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila. Science 1987 ; 237 : 749-753
– reference: 23) 岡田泰伸:Crチャネルの機能・構造と疾患.神経研究の進歩1998;42:263-278
– reference: 5) 岡田泰伸:チャネルとトランスポーターその構造・機能協関と疾病。チャネルとトランスポータ1その働きと病気。メジカルビュー社,!997,H5
– reference: 16) Doyle DA, Cabral JM, Pfuetzner RA , et al : The structure of the potassium channel Molecular basis of K+ conduction and selectivity. Science 1998 ; 280 : 69-77
– reference: 14) Kamb A, Iverson LE, Tanouye MA : Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel. Cell 1987 ; 50 : 405-413
– reference: 1) Hudgkin AL, Huxley AF : Current carried by sodium and potassium ions through the mem brane of the giant axon of Loligo. J Physiol 1952 ; 116 : 449-472
– reference: 3) Neher E, Sakmann B : Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature 1976 ; 260 : 799-802
– reference: 36) Okada Y (ed.) : "Cell volume regulation : The molecular mechanism and volume sensing machinery." Elsevier, Amsterdam, 1998 : 1-214
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イオンチャネル
バイオ分子センサー
細胞容積調節
Title Trends of ion channel researches
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