Synthesis of a Novel Dual Inhibitor of Thromboxane A2 Synthetase and 5-Lipoxygenase (E3040) via the Direct Coupling Reaction of Hydroquinone with 3-Pyridinecarboealdehyde

• Published in: Chemical & pharmaceutical bulletin Vol. 43; no. 10; pp. 1614 - 1616
• Main Authors: KOMATSU, Yuki, MINAMI, Norio
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 15.10.1995; Japan Science and Technology Agency
• Subjects: 2, 6-dimethyl-1, 4-benzohydroquinone; 5-lipoxygenase; direct coupling reaction; dual inhibitor; pyridinecarboxaldehyde; thromboxane A2 synthetase

Synthesis of a novel dual inhibitor of thromboxane A2 synthetase and 5-lipoxygenase, 5, 7-dimethyl-6-hydroxy-2-methylamino-4-(3-pyridylmethyl)benzothiazole (E3040), was accomplished via a new coupling reaction, in which a key intermediate, (3, 6-dihydroxy-2, 4-dimethylphenyl)-(3-pyridyl)methanol, wa...