Pathological findings in a patient with dermatomyositis associated with severe dysphagia
Pathological findings in a patient with dermatomyositis associated with severe dysphagia are presented. Biopsy specimens from several neck muscles of a 70-year-old female patient who under went cricopharyngeal myotomy were obtained. The thyropharyngeal, cricopharyngeal and esophag eal muscles were a...
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| Published in | OTOLOGIA FUKUOKA Vol. 50; no. 6; pp. 494 - 498 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
JIBI TO RINSHO KAI
20.11.2004
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0447-7227 2185-1034 |
| DOI | 10.11334/jibi1954.50.6_494 |
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| Abstract | Pathological findings in a patient with dermatomyositis associated with severe dysphagia are presented. Biopsy specimens from several neck muscles of a 70-year-old female patient who under went cricopharyngeal myotomy were obtained. The thyropharyngeal, cricopharyngeal and esophag eal muscles were atrophied and fibrous, while the platysma, sternocleidomastoid, omohyoid, and sternothyroid muscles were normal. The atrophy and fibrosis of the cricopharyngeal muscle were the findings common to those previously reported. At present, the cause of the atrophy and fibro sis specially of the pharyngeal constrictor muscles or esophageal muscles remains unclarified and therefore requires further examinations. |
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| AbstractList | Pathological findings in a patient with dermatomyositis associated with severe dysphagia are presented. Biopsy specimens from several neck muscles of a 70-year-old female patient who under went cricopharyngeal myotomy were obtained. The thyropharyngeal, cricopharyngeal and esophag eal muscles were atrophied and fibrous, while the platysma, sternocleidomastoid, omohyoid, and sternothyroid muscles were normal. The atrophy and fibrosis of the cricopharyngeal muscle were the findings common to those previously reported. At present, the cause of the atrophy and fibro sis specially of the pharyngeal constrictor muscles or esophageal muscles remains unclarified and therefore requires further examinations. Pathological findings in a patient with dermatomyositis associated with severe dysphagia are presented. Biopsy specimens from several neck muscles of a 70-year-old female patient who under went cricopharyngeal myotomy were obtained. The thyropharyngeal, cricopharyngeal and esophag eal muscles were atrophied and fibrous, while the platysma, sternocleidomastoid, omohyoid, and sternothyroid muscles were normal. The atrophy and fibrosis of the cricopharyngeal muscle were the findings common to those previously reported. At present, the cause of the atrophy and fibro sis specially of the pharyngeal constrictor muscles or esophageal muscles remains unclarified and therefore requires further examinations. 皮膚筋炎により高度の嚥下障害を呈した一症例における病理組織像を検討したので報告をする〇症例は70歳の女性であり、輪状咽頭筋切断術施行時に、病変の伸展範囲を確認するために頸部諸筋からの生検も行った。輪状咽頭筋、甲状咽頭筋、食道筋に筋線維の萎縮や線維化が認められたのに対し、広頸筋、胸鎖乳突筋、肩甲舌骨筋、胸骨甲状筋は、ほぼ正常な組織像であった。輪状咽頭筋の病理組織像は、高度の嚥下障害に対して輪状咽頭筋切断術を行った過去の報告例と同様であり、共通した所見であると考えられた。咽頭収縮筋や食道筋において選択的に炎症が生じ、筋萎縮や線維化に至る原因は、現時点では不明であり、さらなる検討が必要である。 |
| Author | NITO, Takaharu MISAKI, Yoshikata TAKEUCHI, Satoshi YAMAMOTO, Miyuki ADACHI, Nodoka TAYAMA, Niro |
| Author_FL | 山本 美雪 安達 のどか 田山 二朗 二藤 隆春 三崎 義堅 竹内 啓 |
| Author_FL_xml | – sequence: 1 fullname: 二藤 隆春 – sequence: 2 fullname: 三崎 義堅 – sequence: 3 fullname: 竹内 啓 – sequence: 4 fullname: 山本 美雪 – sequence: 5 fullname: 安達 のどか – sequence: 6 fullname: 田山 二朗 |
| Author_xml | – sequence: 1 fullname: TAKEUCHI, Satoshi organization: Department of Otolaryngology, Faculty of Medicine, University of Tokyo – sequence: 1 fullname: TAYAMA, Niro organization: Department of Otolaryngology, International Medical Center of Japan – sequence: 1 fullname: YAMAMOTO, Miyuki organization: Department of Otolaryngology, Faculty of Medicine, University of Tokyo – sequence: 1 fullname: NITO, Takaharu organization: Department of Otolaryngology, Faculty of Medicine, University of Tokyo – sequence: 1 fullname: ADACHI, Nodoka organization: Department of Otolaryngology, Faculty of Medicine, University of Tokyo – sequence: 1 fullname: MISAKI, Yoshikata organization: Department of Allergy and Rheumatology, Faculty of Medicine, University of Tokyo |
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| References | 13) Dietz F et al: Cricopharyngeal muscle dysfunction in the differential diagnosis of dysphagia in polymyositis. Arthritis Rheum 23: 491-495, 1980. 9) 森敏裕他: 多発性筋炎による嚥下障害の1例, 耳鼻36: 99-104, 1990. 11) 兵頭政光他: 高度の難治性嚥下障害を呈した皮膚筋炎症例. 耳鼻50: 244-247, 2004. 8) 兵頭政光他: 多発性筋炎による嚥下障害例の臨床的検討. 喉頭14: 21-24, 2002. 1) Bohan A et al: A computer-assisted analysis of 153 patients with polymyositis and dermatomyositis. Medicine 56: 255-286, 1977. 3) Jacob H et al: The esophageal motility disorder of polymyositis-A prospective study-. Arch Intern Med 143: 2262-2264, 1983. 14) Kagan JK et al: Cricopharyngeal obstruction in inflammatory myopathy (polymyo-sitis/dermatomyositis)-Report of three cases and review of the literature-. Arthritis Rheum 28: 630-636, 1985. 10) 山下弘之他: 輪状咽頭筋切断術の適応と限界. 耳鼻43: 690-695, 1997. 12) Porubsky ES et al: Cricopharyngeal achalasia in dermatomyositis. Arch Otolaryngol 98: 428-429, 1973. 5) 星野功・岡本牧人: 皮膚筋炎・多発性筋炎における嚥下障害. 耳鼻臨床90: 1163-1167, 1997. 7) 森敏裕他: 嚥下障害をきたした多発性筋炎の4例. 耳鼻39: 351-356, 1993. 4) De Merieux P et al: Esophageal abnormalities and dysphagia in polymyositis and dermatomyositis. Arthritis Rheum 26: 961-968, 1983. 15) Vencovsky J et al: Acute cricopharyngeal obstruction in dermatomyositis. J Rheumatol 15: 1016-1018, 1988. 2) Pearson CM: Patterns of polymyositis and their responses to treatment. Ann Intern Med 59: 827-838, 1963. 6) 唐帆健浩他: 皮膚筋炎に伴う嚥下障害の検討. 耳鼻50: 88-92, 2004. |
| References_xml | – reference: 2) Pearson CM: Patterns of polymyositis and their responses to treatment. Ann Intern Med 59: 827-838, 1963. – reference: 8) 兵頭政光他: 多発性筋炎による嚥下障害例の臨床的検討. 喉頭14: 21-24, 2002. – reference: 10) 山下弘之他: 輪状咽頭筋切断術の適応と限界. 耳鼻43: 690-695, 1997. – reference: 5) 星野功・岡本牧人: 皮膚筋炎・多発性筋炎における嚥下障害. 耳鼻臨床90: 1163-1167, 1997. – reference: 6) 唐帆健浩他: 皮膚筋炎に伴う嚥下障害の検討. 耳鼻50: 88-92, 2004. – reference: 4) De Merieux P et al: Esophageal abnormalities and dysphagia in polymyositis and dermatomyositis. Arthritis Rheum 26: 961-968, 1983. – reference: 14) Kagan JK et al: Cricopharyngeal obstruction in inflammatory myopathy (polymyo-sitis/dermatomyositis)-Report of three cases and review of the literature-. Arthritis Rheum 28: 630-636, 1985. – reference: 7) 森敏裕他: 嚥下障害をきたした多発性筋炎の4例. 耳鼻39: 351-356, 1993. – reference: 13) Dietz F et al: Cricopharyngeal muscle dysfunction in the differential diagnosis of dysphagia in polymyositis. Arthritis Rheum 23: 491-495, 1980. – reference: 3) Jacob H et al: The esophageal motility disorder of polymyositis-A prospective study-. Arch Intern Med 143: 2262-2264, 1983. – reference: 9) 森敏裕他: 多発性筋炎による嚥下障害の1例, 耳鼻36: 99-104, 1990. – reference: 11) 兵頭政光他: 高度の難治性嚥下障害を呈した皮膚筋炎症例. 耳鼻50: 244-247, 2004. – reference: 12) Porubsky ES et al: Cricopharyngeal achalasia in dermatomyositis. Arch Otolaryngol 98: 428-429, 1973. – reference: 15) Vencovsky J et al: Acute cricopharyngeal obstruction in dermatomyositis. J Rheumatol 15: 1016-1018, 1988. – reference: 1) Bohan A et al: A computer-assisted analysis of 153 patients with polymyositis and dermatomyositis. Medicine 56: 255-286, 1977. |
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| Title | Pathological findings in a patient with dermatomyositis associated with severe dysphagia |
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