Cytokine of paranasal sinus effusion taken by the YAMIK

• Published in: JIBI INKOKA TEMBO Vol. 44; no. 2; pp. 88 - 96
• Main Authors: Ueda Tsutomu, Takeno Sachio, Kawamoto Hiroko, 古城門 恭介, Hirakawa Katsuhiro, Yajin Koji
• Format: Journal Article
• Language: Japanese
• Published: Society of Oto-rhino-laryngology Tokyo 2001; 耳鼻咽喉科展望会
• Subjects: chronic sinusitis; ELISA法; enzyme-linked immunosorbent assay; nasal allergy; paranasal sinus effusion; YAMIK sinus catheter; YAMIKカテーテル; 副鼻腔貯留液; 慢性副鼻腔炎; 鼻アレルギー
• ISSN: 0386-9687; 1883-6429
• DOI: 10.11453/orltokyo1958.44.88

Chronic sinusitis may coexist with nasal allergy, and chronic sinusitis prognosis is affected by the pressence of nasal allergy.To determaine differences in chronic sinusitis with and without nasal allergy, we measured interleukin-1β (IL-1β), IL-8, tumor necrosis factor-α (TNF-α), IL-4, IL-5, and leukotriene C4/D4/E4 in the paranasal sinus effusion taken by the YAMIK sinus catheter by enzyme-linked immunosorbent assay (ELISA).Subjects were 6 patients with chronic sinusitis with nasal allergy, 8 patients with chronic sinusitis without nasal allergy, and 6 healthy subjects.IL-1β, IL-8, and TNF-α were significantly higher in chronic sinusitis patients than in healthy subjects.No significant difference was seen in IL-1β, IL-8, and TNF-α between the patients of chronic sinusitis with nasal allergy and those without nasal allergy.IL-5 and leukotriene C 4/D 4/E 4 were significantly higher in patients with chronic sinusitis with nasal allergy than in those with chronic sinusitis without nasal allergy and healthy subjects.These results indicate that the degree of infectious inflammatiton in chronic sinusitis with nasal allergy and in chronic sinusitis without nasal allergy is severe and that eosinophilic inflammation occurs in sinus membrane of chronic sinusitis patients with nasal allergy. 慢性副鼻腔炎において, 鼻アレルギーの合併は治療予後に影響することが指摘されてきている。また, YAMIKカテーテルによる治療は, 副鼻腔への有効な薬液移行手段であり, 同時に副鼻腔貯留液を採取できるという利点をもつ。今回我々は, 鼻アレルギー合併による慢性副鼻腔炎病態への影響について検討するために, YAMIKカテーテルにて採取した副鼻腔貯留液のサイトカイン, ロイコトリエン濃度を指標に比較検討した。副鼻腔貯留液中のIL-8, IL-1β, TNF-αは慢性副鼻腔炎症例で正常例より高値であり, 鼻アレルギーの有無による差は認められなかった。またIL-5, ペプタイドロイコトリエンは, 鼻アレルギーを合併する症例において, 合併しない副鼻腔炎症例および正常例より高値であった。以上より, 鼻アレルギー合併副鼻腔炎においては, 感染性炎症と同時に, 好酸球が関与する炎症 (好酸球性炎症) も併存している可能性が示唆された。