Development of a Beverage that Forms a Bubble-Containing Gel in the Stomach and Evaluation of its Gastric Digestion Behavior
Obesity prevention is crucial for controlling lifestyle disease and extending healthy life expectancy. Focusing on the appetite suppression by gastric wall stretching, the company affiliated with the first author developed and evaluated a carbonated beverage that forms a bubble-containing gel under...
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| Published in | Japan Journal of Food Engineering Vol. 26; no. 1; pp. 21 - 29 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japan Society for Food Engineering
15.03.2025
一般社団法人 日本食品工学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1345-7942 1884-5924 |
| DOI | 10.11301/jsfe.24659 |
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| Abstract | Obesity prevention is crucial for controlling lifestyle disease and extending healthy life expectancy. Focusing on the appetite suppression by gastric wall stretching, the company affiliated with the first author developed and evaluated a carbonated beverage that forms a bubble-containing gel under the acidic conditions of gastric juice. A carbonated beverage containing pectin was developed from the viewpoints of easy to intake, stability, and convenience. The findings were obtained regarding the state of the bubble-containing gel in the human stomach and the improvement of satisfaction. Next, we conducted an in vitro evaluation of the bubble-containing gels using the Gastric Digestion Simulator that simulates gastric peristalsis. The results of the analysis indicated that low esterification/high amidation pectin and low citric acid concentration in the beverage improved the swelling and stability of the bubble-containing gel. In 2014, the company affiliated with the first author launched a beverage that forms a bubble-containing gel in the stomach. The results of this study were used for product renewal after 2018. |
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| AbstractList | Obesity prevention is crucial for controlling lifestyle disease and extending healthy life expectancy. Focusing on the appetite suppression by gastric wall stretching, the company affiliated with the first author developed and evaluated a carbonated beverage that forms a bubble-containing gel under the acidic conditions of gastric juice. A carbonated beverage containing pectin was developed from the viewpoints of easy to intake, stability, and convenience. The findings were obtained regarding the state of the bubble-containing gel in the human stomach and the improvement of satisfaction. Next, we conducted an in vitro evaluation of the bubble-containing gels using the Gastric Digestion Simulator that simulates gastric peristalsis. The results of the analysis indicated that low esterification/high amidation pectin and low citric acid concentration in the beverage improved the swelling and stability of the bubble-containing gel. In 2014, the company affiliated with the first author launched a beverage that forms a bubble-containing gel in the stomach. The results of this study were used for product renewal after 2018.
肥満予防は生活習慣病を抑制し健康寿命を延伸させるために重要である．筆頭著者が所属する企業では，胃壁伸展による食欲抑制効果に着目し，胃液の酸性条件下で発泡し気泡含有ゲルを形成する炭酸飲料の開発および評価を行った．服用性，持続性および利便性向上の観点からペクチンを配合した炭酸飲料を開発し，ヒト胃内での気泡含有ゲルの状態および満腹感向上に関する知見を得た．次に，著者らは，胃ぜん動運動を模擬したヒト胃消化シミュレーターを用いて，気泡含有ゲルのin vitro評価を行った．解析の結果，エステル化度が低くアミド化度が高いペクチンを使用するとともに，飲料中のクエン酸濃度を低くすることで，気泡含有ゲルの膨張性および持続性が向上することが示唆された．胃内で気泡含有ゲルを形成する飲料が2014年に筆頭著者が所属する企業より市販され，本研究の成果は，2018年以降の製品リニューアルに活用された． Obesity prevention is crucial for controlling lifestyle disease and extending healthy life expectancy. Focusing on the appetite suppression by gastric wall stretching, the company affiliated with the first author developed and evaluated a carbonated beverage that forms a bubble-containing gel under the acidic conditions of gastric juice. A carbonated beverage containing pectin was developed from the viewpoints of easy to intake, stability, and convenience. The findings were obtained regarding the state of the bubble-containing gel in the human stomach and the improvement of satisfaction. Next, we conducted an in vitro evaluation of the bubble-containing gels using the Gastric Digestion Simulator that simulates gastric peristalsis. The results of the analysis indicated that low esterification/high amidation pectin and low citric acid concentration in the beverage improved the swelling and stability of the bubble-containing gel. In 2014, the company affiliated with the first author launched a beverage that forms a bubble-containing gel in the stomach. The results of this study were used for product renewal after 2018. |
| Author | DOMOTO, Takashi KOZU, Hiroyuki ICHIKAWA, Sosaku KOBAYASHI, Isao |
| Author_FL | 小林 功 堂本 隆史 神津 博幸 市川 創作 |
| Author_FL_xml | – sequence: 1 fullname: 堂本 隆史 – sequence: 2 fullname: 神津 博幸 – sequence: 3 fullname: 小林 功 – sequence: 4 fullname: 市川 創作 |
| Author_xml | – sequence: 1 fullname: KOBAYASHI, Isao organization: Institute of Food Research, NARO – sequence: 1 fullname: ICHIKAWA, Sosaku organization: Institute of Life and Environmental Sciences, University of Tsukuba – sequence: 1 fullname: DOMOTO, Takashi organization: Taisho Pharmaceutical Co., Ltd – sequence: 1 fullname: KOZU, Hiroyuki organization: Institute of Food Research, NARO |
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| DocumentTitleAlternate | 胃内で気泡含有ゲルを形成する飲料の開発と胃消化挙動の評価 |
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| PublicationTitle_FL | Jap J Food Eng Nihon Shokuhin Kogakkaishi 日本食品工学会誌 Japan J. Food Eng Nihon Shokuhin Kougakukaishi Jpn. J. Food Eng |
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| Publisher | Japan Society for Food Engineering 一般社団法人 日本食品工学会 |
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| References | 4) H. Ueno, M. Nakazato; Feeding regulatory substances and obesity (in Japanese). Nihon Naika Gakkai Zasshi, 104, 717-722 (2015). 22) A. J. Wanders, M. Mars, K. J. Borgonjen-van den Berg, C. de Graaf, E. J. M. Feskens; Satiety and energy intake after single and repeated exposure to gel-forming dietary fiber: post-ingestive effects. Int. J. Obes., 38, 794‒800 (2014). 21) H. P. F. Peters, W. P. Koppenol, E. A. H. Schuring, S. L. Abrahamse, D. J. Mela; The effect of a low-energy food foam on appetite measures during a 1-day reduced-energy meal plan. Int. J. Obes., 39, 361‒367 (2015). 23) I. Kobayashi, S. Ichikawa, K. Uemura, H. Kozu, T. Nakata; Stomach model device (in Japanese), Patent No. JP6168585 5) W. T. Philip; Effect of Sibutramine on Cardiovascular Outcomes in Overweight and Obese Subjects. N. Engl. J. Med, 363, 905-917 (2010). 6) M. Camilleri; Peripheral mechanisms in appetite regulation. Gastroenterology, 148, 1219-1233 (2015). 28) D. Lootens, F. Capel, D. Durand, T. Nicolai, P. Boulenguer, V. Langendorff; Influence of pH, Ca concentration, temperature and amidation on the gelation of low methoxyl pectin. Food Hydrocoll., 17, 237-244 (2003). 14) K. Murray, E. Placidi, E. A. H. Schuring, C. L. Hoad, W. Koppenol, L. N. Arnaudov, W. A. M. Blom, S. E. Pritchard, S. D. Stoyanov, P. A. Gowland, R. C. Spiller, H. P. F. Peters, L. Marciani; Aerated drinks increase gastric volume and reduce appetite as assessed by MRI: A randomized, balanced, crossover trial. Am. J. Clin. Nutr., 101, 270-278 (2015). 24) H. Kozu, Y. Nakata, M. Nakajima, M. A. Neves, K. Uemura, S. Sato, I. Kobayashi, S. Ichikawa; Development of a human gastric digestion simulator equipped with peristalsis function for the direct observation and analysis of the food digestion process. Food Sci. Technol. Res., 20, 225-233 (2014). 19) T. Domoto, H. Kozu, M. Nakamura, I. Kobayashi, S. Ichikawa; Effects of the type of pectin and concentration of citric acid on digestive behavior of a bubble-containing gel : evaluation using a human gastric digestion simulator. Jpn. J. Food Eng., 20, 53-60 (2019). 15) V. Strugala, J. Bassin, V. S. Swales, S. W. Lindow, P. W. Dettmar, E. C. M. Thomas; Assessment of the safety and efficacy of a raft-forming alginate reflux suppressant (Liquid Gaviscon) for the treatment of heartburn during pregnancy. Int. Sch. Res. Notices, 2012, 1-6 (2012). 2) D. Kinlen, D. Cody; Complications of obesity. QJM-Int. J. Med., 111, 437-443 (2018). 20) K. Itoh, W. Kubo, M. Fujiwara, H. Watanabe, S. Miyazaki, D. Attwood; The influence of gastric acidity and taste masking agent on in situ gelling pectin formulations for oral sustained delivery of acetaminophen. Biol. Pharm. Bull., 29, 343-347 (2006). 18) T. Domoto, H. Kozu, M. Yamaji, T. Takei, K. Nishijima, K. Matsudo, Y. Mizuma, K. Saisho, I. Kobayashi, S. Ichikawa; Formulation and evaluation of a satiety-inducing carbonated beverage that forms a bubble-containing gel in the stomach. Food Sci. Technol. Res., 24, 435-442 (2018). 17) V. D. Prajapati, G. K. Jani, T. A. Khutliwala, B. S. Zala; Raft forming system - an upcoming approach of gastroretentive drug delivery system. J. Control. Release, 168, 151-165 (2013). 1) S. Miyazaki; Guidelines for the management of obesity disease 2016 (in Japanese). Nihon Naika Gakkai Zasshi, 107, 262-268 (2018). 7) E. K. Williams, R. B. Chang, D. E. Strochlic, B. D. Umas, B. B. Lowell, S. D. Liberles; Sensory neurons that detect stretch and nutrients in the digestive system. Cell, 166, 209-221 (2016). 26) I. Fraeye, T. Duvetter, E. Doungla, V. A. Loey, M. Hendrickx; Fine-tuning the properties of pectin-calcium gels by control of pectin fine structure, gel composition and environmental conditions. Trends Food Sci. Technol., 21, 219-228 (2010). 27) S. Y. Chan, W. S. Choo, D. J. Young, X. J. Loh; Pectin as a rheology modifier: Origin, structure, commercial production and rheology. Carbohydr. Polym., 161, 118-139 (2017). 25) H. Kozu, I. Kobayashi, M. Nakajima, M. A. Neves, K. Uemura, H. Isoda, I. Kobayashi, S. Ichikawa; Mixing characterization of liquid contents in human gastric digestion simulator equipped with gastric secretion and emptying. Biochem. Eng. J., 122, 85-90 (2017). 12) L. Marciani, P. A. Gowland, R. C. Spiller, P. Manoj, R. J. Moore, P. Young, A. J. Fillery-Travis; Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI. Am. J. Physiol.: Gastrointest. Liver Physiol., 280, G1227-G1233 (2001). 13) C. L. Hoad, P. Rayment, R. C. Spiller, L. Marciani, B. D. C. Alonso, C. Traynor, D. J. Mela, H. P. F. Peters, P. A. Gowland; In vivo imaging of intragastric gelation and its effect on satiety in humans. J. Nutr., 134, 2293-2300 (2004). 8) K. M. Horner, N. M. Byrne, G. J. Cleghorn, E. Näslund, N. A. King; The effects of weight loss strategies on gastric emptying and appetite control. Obes. Rev., 12, 935-951 (2011). 10) B. J. Rolls, E. A. Bell, B. A. Waugh; Increasing the volume of a food by incorporating air affects satiety in men. Am. J. Clin. Nutr., 72, 361-368 (2000). 3) H. Yoshimatsu, T. Sakata; Behavior therapy of obesity (in Japanese). Nihon Naika Gakkai Zasshi, 90, 902-913 (2001). 11) S. Wakisaka, H. Nagai, E. Mura, T. Matsumoto, T. Moritani, N. Nagai; The effects of carbonated water upon gastric and cardiac activities and fullness in healthy young women. J. Nutr. Sci. Vitaminol., 58, 333-338 (2012). 9) A. A. Saber, S. Shoar, M. W. Almadani, N. Zundel, M. J. Alkuwari, M. M. Bashah, R. J. Rosenthal; Efficacy of first-time intragastric balloon in weight loss: a systematic review and meta-analysis of randomized controlled trials. Obes. Surg., 27, 1-11 (2017). 16) L. S. Malmud, N. D. Charles, J. Littlefield; The mode of action of alginic acid compound in the reduction of gastroesophageal reflux. J. Nucl. Med., 20, 1023-1028 (1979). |
| References_xml | – reference: 13) C. L. Hoad, P. Rayment, R. C. Spiller, L. Marciani, B. D. C. Alonso, C. Traynor, D. J. Mela, H. P. F. Peters, P. A. Gowland; In vivo imaging of intragastric gelation and its effect on satiety in humans. J. Nutr., 134, 2293-2300 (2004). – reference: 22) A. J. Wanders, M. Mars, K. J. Borgonjen-van den Berg, C. de Graaf, E. J. M. Feskens; Satiety and energy intake after single and repeated exposure to gel-forming dietary fiber: post-ingestive effects. Int. J. Obes., 38, 794‒800 (2014). – reference: 26) I. Fraeye, T. Duvetter, E. Doungla, V. A. Loey, M. Hendrickx; Fine-tuning the properties of pectin-calcium gels by control of pectin fine structure, gel composition and environmental conditions. Trends Food Sci. Technol., 21, 219-228 (2010). – reference: 2) D. Kinlen, D. Cody; Complications of obesity. QJM-Int. J. Med., 111, 437-443 (2018). – reference: 3) H. Yoshimatsu, T. Sakata; Behavior therapy of obesity (in Japanese). Nihon Naika Gakkai Zasshi, 90, 902-913 (2001). – reference: 24) H. Kozu, Y. Nakata, M. Nakajima, M. A. Neves, K. Uemura, S. Sato, I. Kobayashi, S. Ichikawa; Development of a human gastric digestion simulator equipped with peristalsis function for the direct observation and analysis of the food digestion process. Food Sci. Technol. Res., 20, 225-233 (2014). – reference: 16) L. S. Malmud, N. D. Charles, J. Littlefield; The mode of action of alginic acid compound in the reduction of gastroesophageal reflux. J. Nucl. Med., 20, 1023-1028 (1979). – reference: 10) B. J. Rolls, E. A. Bell, B. A. Waugh; Increasing the volume of a food by incorporating air affects satiety in men. Am. J. Clin. Nutr., 72, 361-368 (2000). – reference: 23) I. Kobayashi, S. Ichikawa, K. Uemura, H. Kozu, T. Nakata; Stomach model device (in Japanese), Patent No. JP6168585 – reference: 18) T. Domoto, H. Kozu, M. Yamaji, T. Takei, K. Nishijima, K. Matsudo, Y. Mizuma, K. Saisho, I. Kobayashi, S. Ichikawa; Formulation and evaluation of a satiety-inducing carbonated beverage that forms a bubble-containing gel in the stomach. Food Sci. Technol. Res., 24, 435-442 (2018). – reference: 8) K. M. Horner, N. M. Byrne, G. J. Cleghorn, E. Näslund, N. A. King; The effects of weight loss strategies on gastric emptying and appetite control. Obes. Rev., 12, 935-951 (2011). – reference: 25) H. Kozu, I. Kobayashi, M. Nakajima, M. A. Neves, K. Uemura, H. Isoda, I. Kobayashi, S. Ichikawa; Mixing characterization of liquid contents in human gastric digestion simulator equipped with gastric secretion and emptying. Biochem. Eng. J., 122, 85-90 (2017). – reference: 4) H. Ueno, M. Nakazato; Feeding regulatory substances and obesity (in Japanese). Nihon Naika Gakkai Zasshi, 104, 717-722 (2015). – reference: 7) E. K. Williams, R. B. Chang, D. E. Strochlic, B. D. Umas, B. B. Lowell, S. D. Liberles; Sensory neurons that detect stretch and nutrients in the digestive system. Cell, 166, 209-221 (2016). – reference: 20) K. Itoh, W. Kubo, M. Fujiwara, H. Watanabe, S. Miyazaki, D. Attwood; The influence of gastric acidity and taste masking agent on in situ gelling pectin formulations for oral sustained delivery of acetaminophen. Biol. Pharm. Bull., 29, 343-347 (2006). – reference: 1) S. Miyazaki; Guidelines for the management of obesity disease 2016 (in Japanese). Nihon Naika Gakkai Zasshi, 107, 262-268 (2018). – reference: 12) L. Marciani, P. A. Gowland, R. C. Spiller, P. Manoj, R. J. Moore, P. Young, A. J. Fillery-Travis; Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI. Am. J. Physiol.: Gastrointest. Liver Physiol., 280, G1227-G1233 (2001). – reference: 28) D. Lootens, F. Capel, D. Durand, T. Nicolai, P. Boulenguer, V. Langendorff; Influence of pH, Ca concentration, temperature and amidation on the gelation of low methoxyl pectin. Food Hydrocoll., 17, 237-244 (2003). – reference: 6) M. Camilleri; Peripheral mechanisms in appetite regulation. Gastroenterology, 148, 1219-1233 (2015). – reference: 21) H. P. F. Peters, W. P. Koppenol, E. A. H. Schuring, S. L. Abrahamse, D. J. Mela; The effect of a low-energy food foam on appetite measures during a 1-day reduced-energy meal plan. Int. J. Obes., 39, 361‒367 (2015). – reference: 11) S. Wakisaka, H. Nagai, E. Mura, T. Matsumoto, T. Moritani, N. Nagai; The effects of carbonated water upon gastric and cardiac activities and fullness in healthy young women. J. Nutr. Sci. Vitaminol., 58, 333-338 (2012). – reference: 17) V. D. Prajapati, G. K. Jani, T. A. Khutliwala, B. S. Zala; Raft forming system - an upcoming approach of gastroretentive drug delivery system. J. Control. Release, 168, 151-165 (2013). – reference: 15) V. Strugala, J. Bassin, V. S. Swales, S. W. Lindow, P. W. Dettmar, E. C. M. Thomas; Assessment of the safety and efficacy of a raft-forming alginate reflux suppressant (Liquid Gaviscon) for the treatment of heartburn during pregnancy. Int. Sch. Res. Notices, 2012, 1-6 (2012). – reference: 5) W. T. Philip; Effect of Sibutramine on Cardiovascular Outcomes in Overweight and Obese Subjects. N. Engl. J. Med, 363, 905-917 (2010). – reference: 9) A. A. Saber, S. Shoar, M. W. Almadani, N. Zundel, M. J. Alkuwari, M. M. Bashah, R. J. Rosenthal; Efficacy of first-time intragastric balloon in weight loss: a systematic review and meta-analysis of randomized controlled trials. Obes. Surg., 27, 1-11 (2017). – reference: 27) S. Y. Chan, W. S. Choo, D. J. Young, X. J. Loh; Pectin as a rheology modifier: Origin, structure, commercial production and rheology. Carbohydr. Polym., 161, 118-139 (2017). – reference: 19) T. Domoto, H. Kozu, M. Nakamura, I. Kobayashi, S. Ichikawa; Effects of the type of pectin and concentration of citric acid on digestive behavior of a bubble-containing gel : evaluation using a human gastric digestion simulator. Jpn. J. Food Eng., 20, 53-60 (2019). – reference: 14) K. Murray, E. Placidi, E. A. H. Schuring, C. L. Hoad, W. Koppenol, L. N. Arnaudov, W. A. M. Blom, S. E. Pritchard, S. D. Stoyanov, P. A. Gowland, R. C. Spiller, H. P. F. Peters, L. Marciani; Aerated drinks increase gastric volume and reduce appetite as assessed by MRI: A randomized, balanced, crossover trial. Am. J. Clin. Nutr., 101, 270-278 (2015). |
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| Title | Development of a Beverage that Forms a Bubble-Containing Gel in the Stomach and Evaluation of its Gastric Digestion Behavior |
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