Obstetric outcomes of pregnant women with epilepsy: a retrospective study in a Japanese Perinatal Medical Center

To clarify perinatal management issue for pregnant women with epilepsy, we investigated 58 mothers with epilepsy retrospectively among 15, 344 mothers who had delivery at Japanese Red Cross Medical Center from January 2014 to December 2018. Among 58 mothers, 26 exposed antiepileptic drugs（AEDs）durin...

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Published inJournal of Japan Society of Perinatal and Neonatal Medicine Vol. 57; no. 1; pp. 91 - 97
Main Authors Fujioka, Izumi, Kasai, Yasuyo, Samukawa, Saori, Akutagawa, Kana, Arima, Kaori, Watanabe, Michiko, Miyauchi, Akito
Format Journal Article
LanguageJapanese
Published Japan Society of Perinatal and Neonatal Medicine 2021
Subjects
antiepileptic drug
epilepsy
neonatal outcomes
pregnant women
seizure
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Summary:To clarify perinatal management issue for pregnant women with epilepsy, we investigated 58 mothers with epilepsy retrospectively among 15, 344 mothers who had delivery at Japanese Red Cross Medical Center from January 2014 to December 2018. Among 58 mothers, 26 exposed antiepileptic drugs（AEDs）during pregnancy. Compared women with and without AEDs during pregnancy, there was no significant increase in gestational age at delivery, amount of bleeding, birth weight, Apgar score, and cord blood gas analysis. Epileptic seizures occurred in 13 mothers during pregnancy especially in the mothers who discontinued or switched AEDs after awareness of their pregnancy. Most of mothers（94.8%）were breastfeeding with or without formula. Women with epilepsy should be informed about the necessity of AEDs for seizure control and possibility of adverse effect including congenital anomalies.
ISSN:1348-964X
2435-4996
DOI:10.34456/jjspnm.57.1_91