Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder concomitant with sarcomatoid component revealing a unique form: A case report

A 72-year-old man was referred to our department owing to the wall thickening of the gallbladder. CT and MRI revealed nodular and wall thickening lesions. EUS indicated tumor invasion to a layer of the subserosa. The bile juice cytology revealed adenocarcinoma. Extended cholecystectomy was performed...

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Bibliographic Details
Published inTando Vol. 35; no. 4; pp. 668 - 677
Main Authors Hayashi, Hiroki, Yokoyama, Kensuke, Kanno, Atsushi, Nagai, Hiroki, Ikeda, Eriko, Numao, Norikatsu, Ushio, Jun, Amano, Yusuke, Sasanuma, Hideki, Tamada, Kiichi, Fukushima, Noriyoshi, Sata, Naohiro
Format Journal Article
LanguageJapanese
Published Japan Biliary Association 31.10.2021
Subjects
carcinosarcoma
mixed neuroendocrine-non-neuroendocrine neoplasms
neuroendocrine tumor
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Summary:A 72-year-old man was referred to our department owing to the wall thickening of the gallbladder. CT and MRI revealed nodular and wall thickening lesions. EUS indicated tumor invasion to a layer of the subserosa. The bile juice cytology revealed adenocarcinoma. Extended cholecystectomy was performed; the resected specimen showed a mucosa with irregular surface and a separated fragment. Moreover, pathological findings of the fundus of the gallbladder revealed a tubular adenocarcinoma and a neuroendocrine carcinoma. Furthermore, the histological findings of a separated fragment revealed adenocarcinoma with sarcomatoid tissue. Finally, this lesion was diagnosed as a mixed neuroendocrine-non-neuroendocrine neoplasm with a sarcomatoid component. The complicated histological component may be the cause of the unique form.
ISSN:0914-0077
1883-6879
DOI:10.11210/tando.35.668