Molecular mechanism of organotin toxicity via nuclear receptor signaling

• Published in: Biomedical Research on Trace Elements Vol. 22; no. 1; pp. 15 - 21
• Main Author: Nakanishi, Tsuyoshi
• Format: Journal Article
• Language: English; Japanese
• Published: Osaka Japan Society for Biomedical Research on Trace Elements 2011; Japan Science and Technology Agency
• Subjects: Antifouling substances; Aquatic organisms; aromatase; Biocides; Biosynthesis; endocrine disrupting chemical (EDC); Estrogens; Fishing nets; Fungicides; Genetics; Imposex; organotin; peroxisome proliferator-activated; receptor (PPAR) γ; Repellents; retinoid X receptor (RXR); Toxicity; Tributyltin; Wildlife

Organotin compounds have been widely used as antifouling biocides for ships and fishing nets, agricultural fungicides and rodent repellents. These widespread uses have resulted in the release of increasing amounts of organotins into the environment. In aquatic invertebrates, particularly marine gast...