The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder

• Format: eBook
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: ABC transporter; ACE2; actin; advanced sampling 5; antifungal activity; apparent gas phase activation energies; apparent gas phase dissociation constants; ATP analogues; ATP hydrolysis; backbone atom coordinate variances and uncertainties; binding 2; bioinformatics; biopesticides; cancer; charged amino acids; cofactor binding and release; cytoskeleton; deafness; denatured state ensemble; disordered structure; DnaB helicase; ELDOR-detected NMR; Friedman’s test; gas phase immune complex dissociation; hearing loss; High Hydrostatic Pressure; IDP 1; immunoglobulin domain; insecticidal activity; interdomain cleft dynamics; intrinsically disordered proteins; ion-pairing interaction; ITEM-TWO; mass spectrometric epitope mapping; MDM2 7; mechanism of action; MELD×MD 4; mental illness; molecular dynamics 3; molecular dynamics simulations; n/a; NAD(P)H-dependent oxidoreductase; nanobody; native mass spectrometry; NMR; p53 6; peptide; peptides; protein aggregation; protein coil library; protein folding; protein structure; Reference, Information and Interdisciplinary subjects; Research and information: general; SARS-CoV-2; schizophrenia; side-chain length; solid-state NMR; superimposition; transgenic crops; transmission; TRIOBP; viral spike receptor-binding domain; zinc-containing alcohol dehydrogenase; β-hairpin

Proteins represent one of the most abundant classes of biological macromolecules and play crucial roles in a vast array of physiological and pathological processes. The knowledge of the 3D structure of a protein, as well as the possible conformational transitions occurring upon interaction with dive...