The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking

• Published in: Journal of neurochemistry Vol. 134; no. 6; pp. 1067 - 1080
• Main Authors: Huo, Yuda, Khatri, Natasha, Hou, Qingming, Gilbert, James, Wang, Guan, Man, Heng‐Ye
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2015
• Subjects: AMPA receptor; Animals; Brain; Brain - physiology; deubiquitination; Endopeptidases - metabolism; Enzymes; Excitatory Postsynaptic Potentials - physiology; HEK293 Cells; Humans; Immunohistochemistry; Neurochemistry; Neuronal Plasticity - physiology; Patch-Clamp Techniques; Protein Transport - physiology; Proteins; Radioimmunoprecipitation Assay; Rats; Rats, Sprague-Dawley; receptor internalization; Receptors, AMPA - metabolism; trafficking; Transfection; ubiquitination; Ubiquitination - physiology; USP46; USP46; AMPA receptor; deubiquitination; ubiquitination; trafficking; receptor internalization

Alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPARs) are the primary mediators for inter‐neuronal communication and play a crucial role in higher brain functions including learning and memory. Our previous work demonstrated that AMPARs are subject to ubiquitination by the E3 li...