Advances in therapeutic applications of extracellular vesicles

Extracellular vesicles (EVs) are nanometer-sized, lipid membrane-enclosed vesicles secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid species of the source cell. EVs act as important mediators of intercellular communication that influence both physiological an...

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Published inScience translational medicine Vol. 11; no. 492
Main Authors Wiklander, Oscar P B, Brennan, Meadhbh Á, Lötvall, Jan, Breakefield, Xandra O, El Andaloussi, Samir
Format Journal Article
LanguageEnglish
Published United States 15.05.2019
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Abstract Extracellular vesicles (EVs) are nanometer-sized, lipid membrane-enclosed vesicles secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid species of the source cell. EVs act as important mediators of intercellular communication that influence both physiological and pathological conditions. Given their ability to transfer bioactive components and surmount biological barriers, EVs are increasingly being explored as potential therapeutic agents. EVs can potentiate tissue regeneration, participate in immune modulation, and function as potential alternatives to stem cell therapy, and bioengineered EVs can act as delivery vehicles for therapeutic agents. Here, we cover recent approaches and advances of EV-based therapies.
AbstractList Extracellular vesicles (EVs) are nanometer-sized, lipid membrane-enclosed vesicles secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid species of the source cell. EVs act as important mediators of intercellular communication that influence both physiological and pathological conditions. Given their ability to transfer bioactive components and surmount biological barriers, EVs are increasingly being explored as potential therapeutic agents. EVs can potentiate tissue regeneration, participate in immune modulation, and function as potential alternatives to stem cell therapy, and bioengineered EVs can act as delivery vehicles for therapeutic agents. Here, we cover recent approaches and advances of EV-based therapies.
Author Brennan, Meadhbh Á
El Andaloussi, Samir
Lötvall, Jan
Breakefield, Xandra O
Wiklander, Oscar P B
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  givenname: Oscar P B
  orcidid: 0000-0003-1176-8114
  surname: Wiklander
  fullname: Wiklander, Oscar P B
  email: samir.el-andaloussi@ki.se, oscar.wiklander@ki.se
  organization: Evox Therapeutics Limited, Medawar Centre, Robert Robinson Avenue, Oxford OX4 4HG, UK
– sequence: 2
  givenname: Meadhbh Á
  surname: Brennan
  fullname: Brennan, Meadhbh Á
  organization: INSERM UMR 1238, PhyOS, Faculty of Medicine, Université de Nantes, 44034 Nantes cedex 1, France
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  givenname: Jan
  orcidid: 0000-0001-9195-9249
  surname: Lötvall
  fullname: Lötvall, Jan
  organization: Krefting Research Centre, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden
– sequence: 4
  givenname: Xandra O
  orcidid: 0000-0001-6036-0399
  surname: Breakefield
  fullname: Breakefield, Xandra O
  organization: Departments of Neurology and Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
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  givenname: Samir
  surname: El Andaloussi
  fullname: El Andaloussi, Samir
  email: samir.el-andaloussi@ki.se, oscar.wiklander@ki.se
  organization: Evox Therapeutics Limited, Medawar Centre, Robert Robinson Avenue, Oxford OX4 4HG, UK
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Copyright Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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