Role of caspase 8 as a determinant in chemosensitivity of p53-mutated head and neck squamous cell carcinoma cell lines

• Published in: Journal of Medical and Dental Sciences Vol. 53; no. 1; pp. 57 - 66
• Main Authors: Kaneda, Yoshimasa, Shimamoto, Hiroaki, Matsumura, Kouji, Arvind, Ramanathan, Zhang, Shengliang, Sakai, Eiki, Omura, Ken, Tsuchida, Nobuo
• Format: Journal Article
• Language: English
• Published: Japan Tokyo Medical and Dental University 01.03.2006
• Subjects: Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Apoptosis Regulatory Proteins - pharmacology; Carcinoma, Squamous Cell - enzymology; Carcinoma, Squamous Cell - genetics; Caspase 8; Caspases - physiology; Cell Line, Tumor - drug effects; Cell Line, Tumor - enzymology; Chromones - pharmacology; Cisplatin - pharmacology; Drug Resistance, Neoplasm - genetics; Drug Resistance, Neoplasm - physiology; Etoposide - pharmacology; Fluorouracil - pharmacology; Head and Neck Neoplasms - enzymology; Head and Neck Neoplasms - genetics; Humans; Membrane Glycoproteins - pharmacology; Morpholines - pharmacology; Mutation; Phosphorylation; Proto-Oncogene Proteins c-akt - metabolism; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha - pharmacology; Tumor Suppressor Protein p53 - genetics

We studied factors that control chemoresistance to 6 head and neck squamous cell carcinoma cell lines carrying p53 mutations. Cell lines were chosen, based on the presence of EGFR amplifications, the presence of H-ras mutations, and the absence of either. WST-1 viability assays showed that, in respo...