hybridSPAdes: an algorithm for hybrid assembly of short and long reads

• Published in: Bioinformatics Vol. 32; no. 7; pp. 1009 - 1015
• Main Authors: Antipov, Dmitry, Korobeynikov, Anton, McLean, Jeffrey S, Pevzner, Pavel A
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.04.2016
• Subjects: Algorithms; Assembling; Assembly; Bacteria; Base Sequence; Benchmarking; Bioinformatics; Chromosome Mapping; Cost engineering; Genome; Genomes; Original Papers; Sequence Analysis, DNA

Recent advances in single molecule real-time (SMRT) and nanopore sequencing technologies have enabled high-quality assemblies from long and inaccurate reads. However, these approaches require high coverage by long reads and remain expensive. On the other hand, the inexpensive short reads technologie...