Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and reduction of trans-epidermal water loss: a randomized, double-blind, and placebo-controlled clinical study in healthy humans
Dietary fiber-rich diets are gaining popularity as an alternative therapy for skin health. Plant-based prebiotic partially hydrolyzed guar gum (PHGG) dietary fiber promotes gastrointestinal health, which is imperative for skin health through the gut microbiome. In this randomized, double-blind, and...
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| Published in | Journal of Clinical Biochemistry and Nutrition Vol. 76; no. 1; pp. 96 - 115 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Japan
SOCIETY FOR FREE RADICAL RESEARCH JAPAN
01.01.2025
Japan Science and Technology Agency the Society for Free Radical Research Japan |
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| Abstract | Dietary fiber-rich diets are gaining popularity as an alternative therapy for skin health. Plant-based prebiotic partially hydrolyzed guar gum (PHGG) dietary fiber promotes gastrointestinal health, which is imperative for skin health through the gut microbiome. In this randomized, double-blind, and placebo-controlled study, the purpose was to assess the therapeutic effects of PHGG on skin hydration, trans-epidermal water loss (TEWL), and skin viscoelastic properties during the winter season. Healthy male and female subjects (n = 70; 9 male and 61 female; mean age: 45.5 ± 8.1 years) were recruited. They received either the 5 g PHGG dietary fiber (n = 35) or a 5 g placebo (n = 35) for twelve weeks. Skin moisture, TEWL, skin elasticity and skin color parameters, and related features were assessed at baseline, after 6 and 12 weeks, and questionnaires to evaluate the study outcomes. The results confirmed the improvement in skin conditions throughout the winter season by restoring skin hydration, reducing TEWL, and improving skin elasticity parameters. After 6 weeks of PHGG intake, there was a substantial decrease in TEWL and improvement in viscoelasticity metrics when compared to placebo. Subject satisfaction with efficacy reflected these encouraging findings, and PHGG was well tolerated, with no adverse events occurring during the study period. |
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| AbstractList | Dietary fiber-rich diets are gaining popularity as an alternative therapy for skin health. Plant-based prebiotic partially hydrolyzed guar gum (PHGG) dietary fiber promotes gastrointestinal health, which is imperative for skin health through the gut microbiome. In this randomized, double-blind, and placebo-controlled study, the purpose was to assess the therapeutic effects of PHGG on skin hydration, trans-epidermal water loss (TEWL), and skin viscoelastic properties during the winter season. Healthy male and female subjects (n = 70; 9 male and 61 female; mean age: 45.5 ± 8.1 years) were recruited. They received either the 5 g PHGG dietary fiber (n = 35) or a 5 g placebo (n = 35) for twelve weeks. Skin moisture, TEWL, skin elasticity and skin color parameters, and related features were assessed at baseline, after 6 and 12 weeks, and questionnaires to evaluate the study outcomes. The results confirmed the improvement in skin conditions throughout the winter season by restoring skin hydration, reducing TEWL, and improving skin elasticity parameters. After 6 weeks of PHGG intake, there was a substantial decrease in TEWL and improvement in viscoelasticity metrics when compared to placebo. Subject satisfaction with efficacy reflected these encouraging findings, and PHGG was well tolerated, with no adverse events occurring during the study period. Dietary fiber-rich diets are gaining popularity as an alternative therapy for skin health. Plant-based prebiotic partially hydrolyzed guar gum (PHGG) dietary fiber promotes gastrointestinal health, which is imperative for skin health through the gut microbiome. In this randomized, double-blind, and placebo-controlled study, the purpose was to assess the therapeutic effects of PHGG on skin hydration, trans-epidermal water loss (TEWL), and skin viscoelastic properties during the winter season. Healthy male and female subjects ( n = 70; 9 male and 61 female; mean age: 45.5 ± 8.1 years) were recruited. They received either the 5 g PHGG dietary fiber ( n = 35) or a 5 g placebo ( n = 35) for twelve weeks. Skin moisture, TEWL, skin elasticity and skin color parameters, and related features were assessed at baseline, after 6 and 12 weeks, and questionnaires to evaluate the study outcomes. The results confirmed the improvement in skin conditions throughout the winter season by restoring skin hydration, reducing TEWL, and improving skin elasticity parameters. After 6 weeks of PHGG intake, there was a substantial decrease in TEWL and improvement in viscoelasticity metrics when compared to placebo. Subject satisfaction with efficacy reflected these encouraging findings, and PHGG was well tolerated, with no adverse events occurring during the study period. Dietary fiber-rich diets are gaining popularity as an alternative therapy for skin health. Plant-based prebiotic partially hydrolyzed guar gum (PHGG) dietary fiber promotes gastrointestinal health, which is imperative for skin health through the gut microbiome. In this randomized, double-blind, and placebo-controlled study, the purpose was to assess the therapeutic effects of PHGG on skin hydration, trans-epidermal water loss (TEWL), and skin viscoelastic properties during the winter season. Healthy male and female subjects (n = 70; 9 male and 61 female; mean age: 45.5 ± 8.1 years) were recruited. They received either the 5 g PHGG dietary fiber (n = 35) or a 5 g placebo (n = 35) for twelve weeks. Skin moisture, TEWL, skin elasticity and skin color parameters, and related features were assessed at baseline, after 6 and 12 weeks, and questionnaires to evaluate the study outcomes. The results confirmed the improvement in skin conditions throughout the winter season by restoring skin hydration, reducing TEWL, and improving skin elasticity parameters. After 6 weeks of PHGG intake, there was a substantial decrease in TEWL and improvement in viscoelasticity metrics when compared to placebo. Subject satisfaction with efficacy reflected these encouraging findings, and PHGG was well tolerated, with no adverse events occurring during the study period.Dietary fiber-rich diets are gaining popularity as an alternative therapy for skin health. Plant-based prebiotic partially hydrolyzed guar gum (PHGG) dietary fiber promotes gastrointestinal health, which is imperative for skin health through the gut microbiome. In this randomized, double-blind, and placebo-controlled study, the purpose was to assess the therapeutic effects of PHGG on skin hydration, trans-epidermal water loss (TEWL), and skin viscoelastic properties during the winter season. Healthy male and female subjects (n = 70; 9 male and 61 female; mean age: 45.5 ± 8.1 years) were recruited. They received either the 5 g PHGG dietary fiber (n = 35) or a 5 g placebo (n = 35) for twelve weeks. Skin moisture, TEWL, skin elasticity and skin color parameters, and related features were assessed at baseline, after 6 and 12 weeks, and questionnaires to evaluate the study outcomes. The results confirmed the improvement in skin conditions throughout the winter season by restoring skin hydration, reducing TEWL, and improving skin elasticity parameters. After 6 weeks of PHGG intake, there was a substantial decrease in TEWL and improvement in viscoelasticity metrics when compared to placebo. Subject satisfaction with efficacy reflected these encouraging findings, and PHGG was well tolerated, with no adverse events occurring during the study period. Dietary fiber-rich diets are gaining popularity as an alternative therapy for skin health. Plant-based prebiotic partially hydrolyzed guar gum (PHGG) dietary fiber promotes gastrointestinal health, which is imperative for skin health through the gut microbiome. In this randomized, double-blind, and placebo-controlled study, the purpose was to assess the therapeutic effects of PHGG on skin hydration, trans-epidermal water loss (TEWL), and skin viscoelastic properties during the winter season. Healthy male and female subjects ( = 70; 9 male and 61 female; mean age: 45.5 ± 8.1 years) were recruited. They received either the 5 g PHGG dietary fiber ( = 35) or a 5 g placebo ( = 35) for twelve weeks. Skin moisture, TEWL, skin elasticity and skin color parameters, and related features were assessed at baseline, after 6 and 12 weeks, and questionnaires to evaluate the study outcomes. The results confirmed the improvement in skin conditions throughout the winter season by restoring skin hydration, reducing TEWL, and improving skin elasticity parameters. After 6 weeks of PHGG intake, there was a substantial decrease in TEWL and improvement in viscoelasticity metrics when compared to placebo. Subject satisfaction with efficacy reflected these encouraging findings, and PHGG was well tolerated, with no adverse events occurring during the study period. |
| Author | Ozeki, Makoto Sato, Norio Kapoor, Mahendra P. Abe, Aya Nakajima, Atsushi Morishima, So |
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| Keywords | stratum corneum trans-epidermal water loss hydration viscoelasticity epidermis |
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| References | 26 Hakozaki T, Takiwaki H, Miyamoto K, Sato Y, Arase S. Ultrasound enhanced skin-lightening effect of vitamin C and niacinamide. Skin Res Technol 2006; 12: 105–113. 70 Grice K, Sattar H, Sharratt M, Baker H. Skin temperature and transepidermal water loss. J Invest Dermatol 1971; 57: 108–110. 77 Loutfy I, Abdel Aziz F, Dabbous NI, Hassan MH. Women’s perception and experience of menopause: a community-based study in Alexandria, Egypt. East Mediterr Health J 2006; 12 Suppl 2: S93–S106. 4 Carvalho MJ, Oliveira ALS, Santos Pedrosa S, Pintado M, Pinto-Ribeiro I, Madureira AR. Skin microbiota and the cosmetic industry. Microb Ecol 2023; 86: 86–96. 7 Ogorevc J, Geršak G, Novak D, Drnovšek J. Metrological evaluation of skin conductance measurements. Measurement 2013; 46: 2993–3001. 12 Parker ER. The influence of climate change on skin cancer incidence—a review of the evidence. Int J Womens Dermatol 2021; 7: 17–27. 89 Shahid A, Shen J, Shapiro CM. Measurements of sleepiness and fatigue. J Psychosom Res 2010; 69: 81–89. 30 Ideta R, Sakuta T, Nakano Y, Uchiyama T. Orally administered glucosylceramide improves the skin barrier function by upregulating genes associated with the tight junction and cornified envelope formation. Biosci Biotechnol Biochem 2011; 75: 1516–1523. 53 Kapoor MP, Koido M, Kawaguchi M, et al. Lifestyle related changes with partially hydrolyzed guar gum dietary fiber in healthy athlete individuals—a randomized, double-blind, crossover, placebo-controlled gut microbiome clinical study. J Funct Foods 2020; 72: 104067. 63 Tsukahara K, Hotta M, Fujimura T, Haketa K, Kitahara T. Effect of room humidity on the formation of fine wrinkles in the facial skin of Japanese. Skin Res Technol 2007; 13: 184–188. 33 Shin D, Lee Y, Huang YH, et al. Probiotic fermentation augments the skin anti-photoaging properties of Agastache rugosa through up-regulating antioxidant components in UV-B-irradiated HaCaT keratinocytes. BMC Complement Altern Med 2018; 18: 196. 34 Draelos ZD. Nutrition and enhancing youthful-appearing skin. Clin Dermatol 2010; 28: 400–408. 48 Kapoor MP, Sugita M, Fukuzawa Y, Okubo T. Impact of partially hydrolyzed guar gum (PHGG) on constipation prevention: a systematic review and meta-analysis. J Funct Foods 2017; 33: 52–66. 72 Ryu HS, Joo YH, Kim SO, Park KC, Youn SW. Influence of age and regional differences on skin elasticity as measured by the Cutometer®. Skin Res Technol 2008; 14: 354–358. 81 Ohshima H, Oyobikawa M, Tada A, et al. Melanin and facial skin fluorescence as markers of yellowish discoloration with aging. Skin Res Technol 2009; 15: 496–502. 71 Cunliffe WJ, Burton JL, Shuster S. The effect of local temperature variations on the sebum excretion rate. Br J Dermatol 1970; 83: 650–654. 40 Xiao X, Hu X, Yao J, et al. The role of short-chain fatty acids in inflammatory skin diseases. Front Microbiol 2023; 13: 1083432. 19 Pinson EA. Evaporation from human skin with sweat glands inactivated. Am J Physiol-Legacy Content 1942; 137: 492–503. 22 Camilion JV, Khanna S, Anasseri S, Laney C, Mayrovitz HN. Physiological, pathological, and circadian factors impacting skin hydration. Cureus 2022; 14: e27666. 25 Shoji K, Kameda A, Furuichi K. Effects of milk amazake on skin elasticity, hydration, and transepidermal water loss: an 8-week double-blind, randomized, controlled trial. J Oleo Sci 2023; 72: 329–335. 46 Takahashi T, Tokunaga M, Okubo T, Ozeki M, Kapoor MP, Yasukawa Z. Lower rate of water absorption of an oral rehydration solution with partially hydrolyzed guar gum in conscious rats. Nutrients 2022; 14: 4231. 18 Kapoor MP, Yamaguchi H, Ishida H, Mizutani Y, Timm D, Abe A. The effects of prebiotic partially hydrolyzed guar gum on skin hydration: a randomized, open-label, parallel, controlled study in healthy humans. J Funct Foods 2023; 103: 105494. 85 Van Someren EJW. Sleep propensity is modulated by circadian and behavior-induced changes in cutaneous temperature. J Therm Biol 2004; 29: 437–444. 43 Kapoor MP, Juneja LR. Partially hydrolyzed guar gum dietary fiber. In: Cho SS, Samuel P, eds. Fiber Ingredients: Food Applications and Health Benefits, Boca Raton: CRC Press, 2009; 70–120. 37 Thakkar SK, Moodycliffe AM, Richelle M. Carotenoids and skin. In: Pappas A, ed. Nutrition and Skin: Lessons for Anti-Aging, Beauty and Healthy Skin, New York: Springer, 2011; 59–78. 90 Stephen ID, Coetzee V, Law Smith M, Perrett DI. Skin blood perfusion and oxygenation colour affect perceived human health. PLoS One 2009; 4: e5083. 5 Flores-Balderas X, Peña-Peña M, Rada KM, et al. Beneficial effects of plant-based diets on skin health and inflammatory skin diseases. Nutrients 2023; 15: 2842. 1 Rodan K, Fields K, Majewski G, Falla T. Skincare bootcamp: the evolving role of skincare. Plast Reconstr Surg Glob Open 2016; 4: e1152. 58 Léger D, Gauriau C, Etzi C, et al. “You look sleepy…” The impact of sleep restriction on skin parameters and facial appearance of 24 women. Sleep Med 2022; 89: 97–103. 62 Sato J, Denda M, Chang S, Elias PM, Feingold KR. Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis. J Invest Dermatol 2002; 119: 900–904. 80 Takiwaki H, Miyaoka Y, Kohno H, Arase S. Graphic analysis of the relationship between skin colour change and variations in the amounts of melanin and haemoglobin. Skin Res Technol 2002; 8: 78–83. 51 di Lorenzo R, Bernardi A, Grumetto L, et al. Phenylalanine butyramide is a new cosmetic ingredient with soothing and anti-reddening potential. Molecules 2021; 26: 6611. 14 Voegeli R, Rawlings AV, Summers B. Facial skin pigmentation is not related to stratum corneum cohesion, basal transepidermal water loss, barrier integrity and barrier repair. Int J Cosmet Sci 2015; 37: 241–252. 31 Miyanishi K, Shiono N, Shirai H, Dombo M, Kimata H. Reduction of transepidermal water loss by oral intake of glucosylceramides in patients with atopic eczema. Allergy 2005; 60: 1454–1455. 13 Voegeli R, Rawlings AV, Seroul P, Summers B. A novel continuous colour mapping approach for visualization of facial skin hydration and transepidermal water loss for four ethnic groups. Int J Cosmet Sci 2015; 37: 595–605. 28 Henning SM, Guzman JB, Thames G, et al. Avocado consumption increased skin elasticity and firmness in women—a pilot study. J Cosmet Dermatol 2022; 21: 4028–4034. 42 Chen YE, Fischbach MA, Belkaid Y. Skin microbiota–host interactions. Nature 2018; 553: 427–436. 69 Miyazaki K, Masuoka N, Kano M, Iizuka R. Bifidobacterium fermented milk and galacto-oligosaccharides lead to improved skin health by decreasing phenols production by gut microbiota. Benef Microbes 2014; 5: 121–128. 49 Rosli D, Shahar S, Manaf ZA, et al. Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients. J Parenter Enteral Nutr 2021; 45: 277–286. 21 Mayrovitz HN. Transepidermal water loss and stratum corneum hydration in forearm versus hand palm. Skin Res Technol 2023; 29: e13218. 47 Rao TP, Hayakawa M, Minami T, et al. Post-meal perceivable satiety and subsequent energy intake with intake of partially hydrolysed guar gum. Br J Nutr 2015; 113: 1489–1498. 17 Kikuchi K, Tagami H. Stratum corneum dynamic hydration test. Agache’s Measuring the Skin: Non-invasive Investigations, Physiology, Normal Constants (2nd ed.). Cham: Springer International Publishing, 2015; 341–354. 11 Parke MA, Perez-Sanchez A, Zamil DH, Katta R. Diet and skin barrier: the role of dietary interventions on skin barrier function. Dermatol Pract Concept 2021; 11: e2021132. 39 Wallen-Russell C. Is there a relationship between transepidermal water loss and microbial biodiversity on the skin? Cosmetics 2019; 6: 18. 54 Okubo T, Ishihara N, Takahashi H, et al. Effects of partially hydrolyzed guar gum intake on human intestinal microflora and its metabolism. Biosci Biotechnol Biochem 1994; 58: 1364–1369. 76 Luebberding S, Krueger N, Kerscher M. Skin physiology in men and women: in vivo evaluation of 300 people including TEWL, SC hydration, sebum content and skin surface pH. Int J Cosmet Sci 2013; 35: 477–483. 9 Jang IS, Choi J, Han J, Kim EJ, Lee HK. Differences between cheeks and dorsal hands skin properties during skiing in a cold and windy environment. J Cosmet Dermatol Sci Appl 2017; 7: 27–33. 74 Firooz A, Sadr B, Babakoohi S, et al. Variation of biophysical parameters of the skin with age, gender, and body region. ScientificWorldJournal 2012; 2012: 386936. 91 Sundaram H, Mackiewicz N, Burton E, Peno-Mazzarino L, Lati E, Meunier S. Pilot comparative study of the topical action of a novel, crosslinked resilient hyaluronic acid on skin hydration and barrier function in a dynamic, three-dimensional human explant model. J Drugs Dermatol 2016; 15: 434–441. 24 Chakkalakal M, Nadora D, Gahoonia N, et al. Prospective randomized double-blind placebo-controlled study of oral pomegranate extract on skin wrinkles, biophysical features, and the gut-skin axis. J Clin Med 2022; 11: 6724. 55 Abe A, Morishima S, Kapoor MP, et al. Partially hydrolyzed guar gum is associated with improvement in gut health, sleep, and motivation among healthy subjects. J Clin Biochem Nutr 2023; 72: 189–197. 88 Kräuchi K, Wirz-Justice A. Circadian clues to sleep onset mechanisms. Neuropsychopharmacology 2001; 25 (5 Suppl): S92–S96. 79 Calleja-Agius J, Brincat M. The effect of menopause on the skin and other connective tissues. Gynecol Endocrinol 2012; 28: 273–277. 44 Ohashi Y, Sumitani K, Tokunaga M, Ishihara N, Okubo T, Fujisawa T. Consumption of partially hydrolysed guar gum stimulates Bifidobacteria and butyrate-producing bacteria in the human large intestine. Benef Microbes 2015; 6: 451–455. 57 Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res 1989; 28: 193–213. 16 Kikuchi K, Masuda Y, Yamashita T, Kawai E, Hirao T. Image analysis of skin color heterogeneity focusing on skin chromophores and |
| References_xml | – reference: 35 Bickers DR, Athar M. Oxidative stress in the pathogenesis of skin disease. J Invest Dermatol 2006; 126: 2565–2575. – reference: 54 Okubo T, Ishihara N, Takahashi H, et al. Effects of partially hydrolyzed guar gum intake on human intestinal microflora and its metabolism. Biosci Biotechnol Biochem 1994; 58: 1364–1369. – reference: 36 Richelle M, Sabatier M, Steiling H, Williamson G. Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium. Br J Nutr 2006; 96: 227–238. – reference: 5 Flores-Balderas X, Peña-Peña M, Rada KM, et al. Beneficial effects of plant-based diets on skin health and inflammatory skin diseases. Nutrients 2023; 15: 2842. – reference: 8 Park EH, Jo DJ, Jeon HW, Na SJ. Effects of winter indoor environment on the skin: unveiling skin condition changes in Korea. Skin Res Technol 2023; 29: e13397. – reference: 71 Cunliffe WJ, Burton JL, Shuster S. The effect of local temperature variations on the sebum excretion rate. Br J Dermatol 1970; 83: 650–654. – reference: 62 Sato J, Denda M, Chang S, Elias PM, Feingold KR. Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis. J Invest Dermatol 2002; 119: 900–904. – reference: 77 Loutfy I, Abdel Aziz F, Dabbous NI, Hassan MH. Women’s perception and experience of menopause: a community-based study in Alexandria, Egypt. East Mediterr Health J 2006; 12 Suppl 2: S93–S106. – reference: 63 Tsukahara K, Hotta M, Fujimura T, Haketa K, Kitahara T. Effect of room humidity on the formation of fine wrinkles in the facial skin of Japanese. Skin Res Technol 2007; 13: 184–188. – reference: 3 Oliveira R, Ferreira J, Azevedo LF, Almeida IF. An overview of methods to characterize skin type: focus on visual rating scales and self-report instruments. Cosmetics 2023; 10: 14. – reference: 78 Leitch C, Doherty V, Gebbie A. Women’s perceptions of the effects of menopause and hormone replacement therapy on skin. Menopause Int 2011; 17: 11–13. – reference: 81 Ohshima H, Oyobikawa M, Tada A, et al. Melanin and facial skin fluorescence as markers of yellowish discoloration with aging. Skin Res Technol 2009; 15: 496–502. – reference: 29 Nagata C, Nakamura K, Wada K, et al. Association of dietary fat, vegetables and antioxidant micronutrients with skin ageing in Japanese women. Br J Nutr 2010; 103: 1493–1498. – reference: 21 Mayrovitz HN. Transepidermal water loss and stratum corneum hydration in forearm versus hand palm. Skin Res Technol 2023; 29: e13218. – reference: 30 Ideta R, Sakuta T, Nakano Y, Uchiyama T. Orally administered glucosylceramide improves the skin barrier function by upregulating genes associated with the tight junction and cornified envelope formation. Biosci Biotechnol Biochem 2011; 75: 1516–1523. – reference: 70 Grice K, Sattar H, Sharratt M, Baker H. Skin temperature and transepidermal water loss. J Invest Dermatol 1971; 57: 108–110. – reference: 82 Keshari S, Balasubramaniam A, Myagmardoloonjin B, Herr DR, Negari IP, Huang CM. Butyric acid from probiotic Staphylococcus epidermidis in the skin microbiome down-regulates the ultraviolet-induced pro-inflammatory IL-6 cytokine via short-chain fatty acid receptor. Int J Mol Sci 2019; 20: 4477. – reference: 14 Voegeli R, Rawlings AV, Summers B. Facial skin pigmentation is not related to stratum corneum cohesion, basal transepidermal water loss, barrier integrity and barrier repair. Int J Cosmet Sci 2015; 37: 241–252. – reference: 88 Kräuchi K, Wirz-Justice A. Circadian clues to sleep onset mechanisms. Neuropsychopharmacology 2001; 25 (5 Suppl): S92–S96. – reference: 23 Bolke L, Schlippe G, Gerß J, Voss W. A collagen supplement improves skin hydration, elasticity, roughness, and density: results of a randomized, placebo-controlled, blind study. Nutrients 2019; 11: 2494. – reference: 80 Takiwaki H, Miyaoka Y, Kohno H, Arase S. Graphic analysis of the relationship between skin colour change and variations in the amounts of melanin and haemoglobin. Skin Res Technol 2002; 8: 78–83. – reference: 48 Kapoor MP, Sugita M, Fukuzawa Y, Okubo T. Impact of partially hydrolyzed guar gum (PHGG) on constipation prevention: a systematic review and meta-analysis. J Funct Foods 2017; 33: 52–66. – reference: 24 Chakkalakal M, Nadora D, Gahoonia N, et al. Prospective randomized double-blind placebo-controlled study of oral pomegranate extract on skin wrinkles, biophysical features, and the gut-skin axis. J Clin Med 2022; 11: 6724. – reference: 55 Abe A, Morishima S, Kapoor MP, et al. Partially hydrolyzed guar gum is associated with improvement in gut health, sleep, and motivation among healthy subjects. J Clin Biochem Nutr 2023; 72: 189–197. – reference: 19 Pinson EA. Evaporation from human skin with sweat glands inactivated. Am J Physiol-Legacy Content 1942; 137: 492–503. – reference: 20 Chilcott RP, Dalton CH, Emmanuel AJ, Allen CE, Bradley ST. Transepidermal water loss does not correlate with skin barrier function in vitro. J Invest Dermatol 2002; 118: 871–875. – reference: 32 Dreher ML, Davenport AJ. Hass avocado composition and potential health effects. Crit Rev Food Sci Nutr 2013; 53: 738–750. – reference: 52 Salem I, Ramser A, Isham N, Ghannoum MA. The gut microbiome as a major regulator of the gut-skin axis. Front Microbiol 2018; 9: 1459. – reference: 79 Calleja-Agius J, Brincat M. The effect of menopause on the skin and other connective tissues. Gynecol Endocrinol 2012; 28: 273–277. – reference: 83 Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 2014; 20: 159–166. – reference: 17 Kikuchi K, Tagami H. Stratum corneum dynamic hydration test. Agache’s Measuring the Skin: Non-invasive Investigations, Physiology, Normal Constants (2nd ed.). Cham: Springer International Publishing, 2015; 341–354. – reference: 34 Draelos ZD. Nutrition and enhancing youthful-appearing skin. Clin Dermatol 2010; 28: 400–408. – reference: 74 Firooz A, Sadr B, Babakoohi S, et al. Variation of biophysical parameters of the skin with age, gender, and body region. ScientificWorldJournal 2012; 2012: 386936. – reference: 51 di Lorenzo R, Bernardi A, Grumetto L, et al. Phenylalanine butyramide is a new cosmetic ingredient with soothing and anti-reddening potential. Molecules 2021; 26: 6611. – reference: 72 Ryu HS, Joo YH, Kim SO, Park KC, Youn SW. Influence of age and regional differences on skin elasticity as measured by the Cutometer®. Skin Res Technol 2008; 14: 354–358. – reference: 10 Song EJ, Lee JA, Park JJ, et al. A study on seasonal variation of skin parameters in Korean males. Int J Cosmet Sci 2015; 37: 92–97. – reference: 39 Wallen-Russell C. Is there a relationship between transepidermal water loss and microbial biodiversity on the skin? Cosmetics 2019; 6: 18. – reference: 43 Kapoor MP, Juneja LR. Partially hydrolyzed guar gum dietary fiber. In: Cho SS, Samuel P, eds. Fiber Ingredients: Food Applications and Health Benefits, Boca Raton: CRC Press, 2009; 70–120. – reference: 68 Japan Meteorological Agency/Ministry of Land, Infrastructure, Transport and Tourism, Japan. https://www.jma.go.jp/. Accessed 26 Jun 2024. – reference: 45 Takagi T, Naito Y, Higashimura Y, et al. Partially hydrolysed guar gum ameliorates murine intestinal inflammation in association with modulating luminal microbiota and SCFA. Br J Nutr 2016; 116: 1199–1205. – reference: 50 Niv E, Halak A, Tiommny E, et al. Randomized clinical study: partially hydrolyzed guar gum (PHGG) versus placebo in the treatment of patients with irritable bowel syndrome. Nutr Metab (Lond) 2016; 13: 10. – reference: 56 Goodyear MD, Krleza-Jeric K, Lemmens T. The declaration of Helsinki. BMJ 2007; 335: 624–625. – reference: 12 Parker ER. The influence of climate change on skin cancer incidence—a review of the evidence. Int J Womens Dermatol 2021; 7: 17–27. – reference: 69 Miyazaki K, Masuoka N, Kano M, Iizuka R. Bifidobacterium fermented milk and galacto-oligosaccharides lead to improved skin health by decreasing phenols production by gut microbiota. Benef Microbes 2014; 5: 121–128. – reference: 18 Kapoor MP, Yamaguchi H, Ishida H, Mizutani Y, Timm D, Abe A. The effects of prebiotic partially hydrolyzed guar gum on skin hydration: a randomized, open-label, parallel, controlled study in healthy humans. J Funct Foods 2023; 103: 105494. – reference: 9 Jang IS, Choi J, Han J, Kim EJ, Lee HK. Differences between cheeks and dorsal hands skin properties during skiing in a cold and windy environment. J Cosmet Dermatol Sci Appl 2017; 7: 27–33. – reference: 7 Ogorevc J, Geršak G, Novak D, Drnovšek J. Metrological evaluation of skin conductance measurements. Measurement 2013; 46: 2993–3001. – reference: 27 Genovese L, Corbo A, Sibilla S. An insight into the changes in skin texture and properties following dietary intervention with a nutricosmeceutical containing a blend of collagen bioactive peptides and antioxidants. Skin Pharmacol Physiol 2017; 30: 146–158. – reference: 66 Rawlings AV, Matts PJ. Stratum corneum moisturization at the molecular level: an update in relation to the dry skin cycle. J Invest Dermatol 2005; 124: 1099–1110. – reference: 42 Chen YE, Fischbach MA, Belkaid Y. Skin microbiota–host interactions. Nature 2018; 553: 427–436. – reference: 40 Xiao X, Hu X, Yao J, et al. The role of short-chain fatty acids in inflammatory skin diseases. Front Microbiol 2023; 13: 1083432. – reference: 84 Trompette A, Pernot J, Perdijk O, et al. Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation. Mucosal Immunol 2022; 15: 908–926. – reference: 75 Cua AB, Wilhelm KP, Maibach HI. Elastic properties of human skin: relation to age, sex, and anatomical region. Arch Dermatol Res 1990; 282: 283–288. – reference: 76 Luebberding S, Krueger N, Kerscher M. Skin physiology in men and women: in vivo evaluation of 300 people including TEWL, SC hydration, sebum content and skin surface pH. Int J Cosmet Sci 2013; 35: 477–483. – reference: 85 Van Someren EJW. Sleep propensity is modulated by circadian and behavior-induced changes in cutaneous temperature. J Therm Biol 2004; 29: 437–444. – reference: 91 Sundaram H, Mackiewicz N, Burton E, Peno-Mazzarino L, Lati E, Meunier S. Pilot comparative study of the topical action of a novel, crosslinked resilient hyaluronic acid on skin hydration and barrier function in a dynamic, three-dimensional human explant model. J Drugs Dermatol 2016; 15: 434–441. – reference: 33 Shin D, Lee Y, Huang YH, et al. Probiotic fermentation augments the skin anti-photoaging properties of Agastache rugosa through up-regulating antioxidant components in UV-B-irradiated HaCaT keratinocytes. BMC Complement Altern Med 2018; 18: 196. – reference: 25 Shoji K, Kameda A, Furuichi K. Effects of milk amazake on skin elasticity, hydration, and transepidermal water loss: an 8-week double-blind, randomized, controlled trial. J Oleo Sci 2023; 72: 329–335. – reference: 58 Léger D, Gauriau C, Etzi C, et al. “You look sleepy…” The impact of sleep restriction on skin parameters and facial appearance of 24 women. Sleep Med 2022; 89: 97–103. – reference: 73 Hori M, Kishimoto S, Tezuka Y, et al. Double-blind study on effects of glucosyl ceramide in beet extract on skin elasticity and fibronectin production in human dermal fibroblasts. Anti-Aging Med 2010; 7: 129–142. – reference: 28 Henning SM, Guzman JB, Thames G, et al. Avocado consumption increased skin elasticity and firmness in women—a pilot study. J Cosmet Dermatol 2022; 21: 4028–4034. – reference: 37 Thakkar SK, Moodycliffe AM, Richelle M. Carotenoids and skin. In: Pappas A, ed. Nutrition and Skin: Lessons for Anti-Aging, Beauty and Healthy Skin, New York: Springer, 2011; 59–78. – reference: 57 Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res 1989; 28: 193–213. – reference: 44 Ohashi Y, Sumitani K, Tokunaga M, Ishihara N, Okubo T, Fujisawa T. Consumption of partially hydrolysed guar gum stimulates Bifidobacteria and butyrate-producing bacteria in the human large intestine. Benef Microbes 2015; 6: 451–455. – reference: 2 De Pessemier B, Grine L, Debaere M, Maes A, Paetzold B, Callewaert C. Gut–skin axis: current knowledge of the interrelationship between microbial dysbiosis and skin conditions. Microorganisms 2021; 9: 353. – reference: 49 Rosli D, Shahar S, Manaf ZA, et al. Randomized controlled trial on the effect of partially hydrolyzed guar gum supplementation on diarrhea frequency and gut microbiome count among pelvic radiation patients. J Parenter Enteral Nutr 2021; 45: 277–286. – reference: 89 Shahid A, Shen J, Shapiro CM. Measurements of sleepiness and fatigue. J Psychosom Res 2010; 69: 81–89. – reference: 47 Rao TP, Hayakawa M, Minami T, et al. Post-meal perceivable satiety and subsequent energy intake with intake of partially hydrolysed guar gum. Br J Nutr 2015; 113: 1489–1498. – reference: 61 Sato J, Katagiri C, Nomura J, Denda M. Drastic decrease in environmental humidity decreases water-holding capacity and free amino acid content of the stratum corneum. Arch Dermatol Res 2001; 293: 477–480. – reference: 11 Parke MA, Perez-Sanchez A, Zamil DH, Katta R. Diet and skin barrier: the role of dietary interventions on skin barrier function. Dermatol Pract Concept 2021; 11: e2021132. – reference: 90 Stephen ID, Coetzee V, Law Smith M, Perrett DI. Skin blood perfusion and oxygenation colour affect perceived human health. PLoS One 2009; 4: e5083. – reference: 64 Berardesca E, Maibach HI. Transepidermal water loss and skin surface hydration in the non invasive assessment of stratum corneum function. Derm Beruf Umwelt 1990; 38: 50–53. – reference: 41 Lee HJ, Kim M. Skin barrier function and the microbiome. Int J Mol Sci 2022; 23: 13071. – reference: 60 Kapoor MP, Sugita M, Kawaguchi M, et al. Influence of iron supplementation on fatigue, mood states and sweating profiles of healthy non-anemic athletes during a training exercise: a double-blind, randomized, placebo-controlled, parallel-group study. Contemp Clin Trials Commun 2023; 32: 101084. – reference: 4 Carvalho MJ, Oliveira ALS, Santos Pedrosa S, Pintado M, Pinto-Ribeiro I, Madureira AR. Skin microbiota and the cosmetic industry. Microb Ecol 2023; 86: 86–96. – reference: 59 Takiwaki H, Miyamoto H, Ahsan K. A simple method to estimate CIE-L*a*b* values of the skin from its videomicroscopic image. Skin Res Technol 1997; 3: 42–44. – reference: 16 Kikuchi K, Masuda Y, Yamashita T, Kawai E, Hirao T. Image analysis of skin color heterogeneity focusing on skin chromophores and the age-related changes in facial skin. Skin Res Technol 2015; 21: 175–183. – reference: 86 Benca RM, Obermeyer WH, Thisted RA, Gillin JC. Sleep and psychiatric disorders: a meta-analysis. Arch Gen Psychiatry 1992; 49: 651–668. – reference: 13 Voegeli R, Rawlings AV, Seroul P, Summers B. A novel continuous colour mapping approach for visualization of facial skin hydration and transepidermal water loss for four ethnic groups. Int J Cosmet Sci 2015; 37: 595–605. – reference: 38 Coates M, Lee MJ, Norton D, MacLeod AS. The skin and intestinal microbiota and their specific innate immune systems. Front Immunol 2019; 10: 2950. – reference: 46 Takahashi T, Tokunaga M, Okubo T, Ozeki M, Kapoor MP, Yasukawa Z. Lower rate of water absorption of an oral rehydration solution with partially hydrolyzed guar gum in conscious rats. Nutrients 2022; 14: 4231. – reference: 87 Sundelin T, Lekander M, Kecklund G, Van Someren EJ, Olsson A, Axelsson J. Cues of fatigue: effects of sleep deprivation on facial appearance. Sleep 2013; 36: 1355–1360. – reference: 22 Camilion JV, Khanna S, Anasseri S, Laney C, Mayrovitz HN. Physiological, pathological, and circadian factors impacting skin hydration. Cureus 2022; 14: e27666. – reference: 65 Grubauer G, Elias PM, Feingold KR. Transepidermal water loss: the signal for recovery of barrier structure and function. J Lipid Res 1989; 30: 323–333. – reference: 31 Miyanishi K, Shiono N, Shirai H, Dombo M, Kimata H. Reduction of transepidermal water loss by oral intake of glucosylceramides in patients with atopic eczema. Allergy 2005; 60: 1454–1455. – reference: 67 Huang HC, Chang TM. Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin. Int J Dermatol 2008; 47: 812–819. – reference: 6 Cao C, Xiao Z, Wu Y, Ge C. Diet and skin aging—from the perspective of food nutrition. Nutrients 2020; 12: 870. – reference: 15 Palma L, Marques LT, Bujan J, Rodrigues LM. Dietary water affects human skin hydration and biomechanics. Clin Cosmet Investig Dermatol 2015; 8: 413–421. – reference: 26 Hakozaki T, Takiwaki H, Miyamoto K, Sato Y, Arase S. Ultrasound enhanced skin-lightening effect of vitamin C and niacinamide. Skin Res Technol 2006; 12: 105–113. – reference: 1 Rodan K, Fields K, Majewski G, Falla T. Skincare bootcamp: the evolving role of skincare. Plast Reconstr Surg Glob Open 2016; 4: e1152. – reference: 53 Kapoor MP, Koido M, Kawaguchi M, et al. Lifestyle related changes with partially hydrolyzed guar gum dietary fiber in healthy athlete individuals—a randomized, double-blind, crossover, placebo-controlled gut microbiome clinical study. J Funct Foods 2020; 72: 104067. |
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| SubjectTerms | Clinical trials Dietary fiber epidermis Females Guar gum Hydration Intestinal microflora Males Microbiomes Original Parameters Placebos Prebiotics Skin diseases Stratum corneum trans-epidermal water loss Viscoelasticity Water loss Winter |
| Title | Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and reduction of trans-epidermal water loss: a randomized, double-blind, and placebo-controlled clinical study in healthy humans |
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