The roles of SOCS3 and STAT3 in bacterial infection and inflammatory diseases

• Published in: Scandinavian journal of immunology Vol. 88; no. 6; pp. e12727 - n/a
• Main Authors: Gao, Yu, Zhao, Honglei, Wang, Peng, Wang, Jun, Zou, Lili
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.12.2018
• Subjects: Animals; bacterial infection; Bacterial Infections - immunology; Biodegradation; Cell Death; Cell Proliferation; Cytokines; Gene Expression Regulation; Growth factors; Humans; Infections; inflammation; Inflammation - immunology; Inflammatory diseases; Interleukin-10 - metabolism; Interleukin-6 - metabolism; JAK; Janus kinase; Lymphoid cells; Medicin och hälsovetenskap; Phosphorylation; Proteasomes; Signal Transduction; SOCS; SOCS3; STAT3; Stat3 protein; STAT3 Transcription Factor - metabolism; Suppressor of Cytokine Signaling 3 Protein - genetics; Suppressor of Cytokine Signaling 3 Protein - metabolism; Transcription; Ubiquitination; SOCS3; JAK; inflammation; STAT3; SOCS; cytokines; bacterial infection

The suppressor of cytokine signalling‐3 (SOCS3) is well known as a feedback inhibitor of the Janus kinases‐signal transducer and activator of transcription 3 (JAK/STAT3) signalling pathway, which mediates the signal transduction of many cytokines, growth factors and hormones during many cellular pro...