mTORC1 and mTORC2 as regulators of cell metabolism in immunity

• Published in: FEBS letters Vol. 591; no. 19; pp. 3089 - 3103
• Main Authors: Linke, Monika, Fritsch, Stephanie Deborah, Sukhbaatar, Nyamdelger, Hengstschläger, Markus, Weichhart, Thomas
• Format: Journal Article
• Language: English
• Published: England 01.10.2017
• Subjects: Animals; antigen presentation; Cells - metabolism; dendritic cell; energy; energy metabolism; glycolysis; hematopoietic stem cells; homeostasis; Humans; immune cell metabolism; Immunity; lipid metabolism; lipids; macrophage; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; memory; mitochondria; Mitochondria - metabolism; Models, Biological; mTORC1; mTORC2; Multiprotein Complexes - metabolism; protein synthesis; rapamycin; T-lymphocytes; TOR Serine-Threonine Kinases - metabolism; T‐cell; T-cell; mitochondria; glycolysis; immune cell metabolism; lipid metabolism; macrophage; mTORC2; mTORC1; dendritic cell

The mechanistic target of rapamycin (mTOR) pathway is an evolutionarily conserved signaling pathway that senses intra‐ and extracellular nutrients, growth factors, and pathogen‐associated molecular patterns to regulate the function of innate and adaptive immune cell populations. In this review, we f...