Regulation of natural competence by the orphan two‐component system sensor kinase ChiS involves a non‐canonical transmembrane regulator in Vibrio cholerae

• Published in: Molecular microbiology Vol. 91; no. 2; pp. 326 - 347
• Main Authors: Yamamoto, Shouji, Mitobe, Jiro, Ishikawa, Takahiko, Wai, Sun Nyunt, Ohnishi, Makoto, Watanabe, Haruo, Izumiya, Hidemasa
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.01.2014
• Subjects: Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Chitin - metabolism; Chromosomes; Cytoplasm; Deoxyribonucleic acid; DNA; E coli; Escherichia coli; Gene expression; Gene Expression Regulation, Bacterial; Molecular Sequence Data; Proteins; Signal Transduction; Vibrio cholerae; Vibrio cholerae - metabolism; Vibrio cholerae - physiology

Summary In Vibrio cholerae, 41 chitin‐inducible genes, including the genes involved in natural competence for DNA uptake, are governed by the orphan two‐component system (TCS) sensor kinase ChiS. However, the mechanism by which ChiS controls the expression of these genes is currently unknown. Here,...