EFFECT OF PROTEIN-BOUND POLYSACCHARIDE PREPARATION, PS-K, ON THE IMMUNE RESPONSE OF MICE TO SHEEP RED BLOOD CELLS

• Published in: GANN Japanese Journal of Cancer Research Vol. 67; no. 1; pp. 97 - 99
• Main Authors: YOKOMAKU, Shozo, IMAI, Kuniyuki, YAMADA, Kazumasa, SUGIURA, Sayoko, OHNO, Ryuzo, WAKAYAMA, Kikuko
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Cancer Association 01.01.1976; 日本癌学会
• Subjects: Animals; Antibody Formation; Antitumor protein-bound polysaccharide, PS-K; Basidiomycota - analysis; C57BL/6 mouse; Erythrocytes - immunology; Female; Hemagglutinins - analysis; Hemolytic Plaque Technique; Immunopotentiator; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Polysaccharides - administration & dosage; Polysaccharides - immunology; Protein Binding; Spleen - cytology
• ISSN: 0016-450X
• DOI: 10.20772/cancersci1959.67.1_97

The protein-bound polysaccharide preparation, PS-K, was found to potentiate the production of hemolytic plaque-forming cells of spleen and serum hemagglutinin in C57BL/6 mice, when they were immunized with a low dose of sheep red blood cells. PS-K was administered intraperitoneally at a dose of 150mg/kg daily for 5 days. Ten days later, the mice were immunized with either 4×108 or 1×107 sheep red blood cells. Both the number of plaque-forming cells in their spleen and the amount of serum hemagglutinin were significantly higher in the PS-K treated mice when 1×107 sheep red blood cells were used as an immunizing dose.