Pharmacological evidence for the 5‐HT7 receptor mediating smooth muscle relaxation in canine cerebral arteries

• Published in: British journal of pharmacology Vol. 127; no. 3; pp. 609 - 616
• Main Authors: TERRON, J. A, FALCON-NERI, A
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.1999; Nature Publishing
• Subjects: 5‐HT7 receptor; 5‐hydroxytryptamine; Animals; Basilar artery; Basilar Artery - drug effects; Basilar Artery - physiology; Biological and medical sciences; Blood vessels and receptors; Cerebral Arteries - drug effects; Cerebral Arteries - physiology; Dinoprost - pharmacology; Dogs; Endothelium, Vascular - physiology; Female; Fundamental and applied biological sciences. Psychology; In Vitro Techniques; Male; middle cerebral artery; migraine; Muscle Relaxation - drug effects; Muscle Relaxation - physiology; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - physiology; Receptors, Serotonin - physiology; relaxation; Serotonin - analogs & derivatives; Serotonin - pharmacology; Serotonin Receptor Agonists - pharmacology; Spiperone - pharmacology; Sumatriptan - pharmacology; vascular smooth muscle; Vertebrates: cardiovascular system; Fissipedia; Carnivora; Serotonin; Smooth muscle; Serotonine receptor; Cerebral artery; In vitro; Vasodilation; Muscular relaxation; Vertebrata; Mammalia; Neuromediator; Blood vessel; Animal; Circulatory system; Dog

We investigated in the present study whether 5‐HT is able to exert direct relaxant responses in canine basilar and middle cerebral arteries via the 5‐HT7 receptor. In arterial rings deprived of endothelium and pre‐contracted with prostaglandin F2α (2 μM), 5‐HT, 5‐carboxamidotryptamine (5‐CT), 5‐meth...