ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression

• Published in: Cancer science Vol. 104; no. 3; pp. 321 - 327
• Main Authors: Fujii, Tomomi, Shimada, Keiji, Anai, Satoshi, Fujimoto, Kiyohide, Konishi, Noboru
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.03.2013
• Subjects: AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Animals; Cadherins - metabolism; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dioxygenases - metabolism; Disease Progression; DNA Repair Enzymes - metabolism; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Mice; Mucin-1 - genetics; Mucin-1 - metabolism; Neoplasm Transplantation; Original; Transfection; Transplantation, Heterologous; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology; Vimentin - metabolism

The ALKBH family of proteins are highly expressed in various types of human cancer where they are involved in tumor growth and progression. However, multiple isoforms of ALKBH exist and the effect of individual isoforms on the development of urinary bladder cancer is unknown, particularly the molecu...