Combination of anti‐CD4 antibody treatment and donor lymphocyte infusion ameliorates graft‐versus‐host disease while preserving graft‐versus‐tumor effects in murine allogeneic hematopoietic stem cell transplantation

• Published in: Cancer science Vol. 108; no. 10; pp. 1967 - 1973
• Main Authors: Ueha, Satoshi, Yokochi, Shoji, Ishiwata, Yoshiro, Kosugi‐Kanaya, Mizuha, Shono, Yusuke, Shibayama, Shiro, Ito, Satoru, Matsushima, Kouji
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.10.2017
• Subjects: Allogeneic hematopoietic stem cell transplantation; Animals; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - pharmacology; CD4; CD4 Antigens - immunology; Cell Line, Tumor; Colonic Neoplasms - therapy; Combined Modality Therapy; Disease Models, Animal; donor lymphocyte infusion; Graft vs Host Disease - immunology; Graft vs Host Disease - therapy; graft‐versus‐host disease; graft‐versus‐tumor; Hematopoietic Stem Cell Transplantation - mortality; Immunotherapy, Adoptive - methods; Lymphocyte Transfusion - methods; Mice; Original; Survival Analysis; Transplantation Conditioning; Transplantation, Homologous - mortality; Treatment Outcome; graft-versus-tumor; CD4; Allogeneic hematopoietic stem cell transplantation; donor lymphocyte infusion; graft-versus-host disease

Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is not only a well‐established immunotherapy for hematologic malignancies, but is potentially useful for treating solid tumors refractory to available therapies. However, application of allo‐HSCT to solid tumors is limited, despite the b...