HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF‐1 expression and activates Wnt pathway

• Published in: Cancer science Vol. 104; no. 12; pp. 1675 - 1682
• Main Authors: Ge, Xiao‐Song, Ma, Hua‐Juan, Zheng, Xiao‐Hui, Ruan, Hong‐Lian, Liao, Xiao‐Yu, Xue, Wen‐Qiong, Chen, Yuan‐Bin, Zhang, Ying, Jia, Wei‐Hua
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.12.2013
• Subjects: Adaptor Proteins, Signal Transducing - biosynthesis; Adaptor Proteins, Signal Transducing - metabolism; Adult; Aged; Aged, 80 and over; beta Catenin - metabolism; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Cell Line, Tumor; DNA Methylation; Esophageal Neoplasms - genetics; Esophageal Neoplasms - metabolism; Female; Fibroblast Growth Factors - metabolism; Forkhead Transcription Factors - metabolism; Gene Expression Regulation, Neoplastic; Histones - metabolism; Humans; Male; Middle Aged; Neoplasm Metastasis - genetics; Original; Promoter Regions, Genetic; Receptors, CXCR - metabolism; Repressor Proteins - biosynthesis; Repressor Proteins - metabolism; RNA Interference; RNA, Long Noncoding - biosynthesis; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Small Interfering - genetics; Up-Regulation; Wnt Proteins - metabolism; Wnt Signaling Pathway
• ISSN: 1347-9032; 1349-7006; 1349-7006
• DOI: 10.1111/cas.12296

Long non‐coding RNAs (LncRNAs) have been recently found to be pervasively transcribed in the genome and critical regulators of the epigenome. HOTAIR, as a well‐known LncRNA, has been found to play important roles in several tumors. Herein, the clinical application value and biological functions of H...