THE CAPACITY OF ANTIGEN-PRESENTING CELLS IS FULLY PRESERVED IN CHILDHOOD CANCER PATIENTS

T cells from 19 out of 25 childhood cancer patients showed impaired proliferative responses to purified protein derivatives (PPD)-pulsed antigen-presenting cells (APC) although all of the patients had been immunized with BCG. To test whether such low responsiveness of T cells results from the dysfun...

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Published inGANN Japanese Journal of Cancer Research Vol. 75; no. 12; pp. 1108 - 1115
Main Authors KOIDE, Yukio, HONGO, Teruaki, ISEKI, Rieko, MORI, Yasuo, YOSHIDA, Takato O.
Format Journal Article
LanguageEnglish
Published Japan The Japanese Cancer Association 01.01.1984
Subjects
Adolescent
Antigen-presenting cells
Antigen-Presenting Cells - immunology
Child
Child, Preschool
Childhood cancer
Concanavalin A - pharmacology
Humans
Infant
Lymphocyte Activation
Neoplasms - immunology
Phytohemagglutinins - pharmacology
PPD
T cell proliferative responses
T-Lymphocytes - immunology
T-Lymphocytes, Regulatory - immunology
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Summary:T cells from 19 out of 25 childhood cancer patients showed impaired proliferative responses to purified protein derivatives (PPD)-pulsed antigen-presenting cells (APC) although all of the patients had been immunized with BCG. To test whether such low responsiveness of T cells results from the dysfunction of T cells or from that of APC, the experiment was designed to assess the proliferative response of T cells from patients or their parents to PPD-pulsed APC from patients or parents. These combinations seem to be suitable to assess the activity of T cells or APC since at least partial identity of HLA-D/DR antigens is required for T cell-APC interactions. Although T cells from patients who showed low responsiveness to PPD failed to respond even to PPD-pulsed APC from parents, T cells from parents were able to respond to PPD-pulsed APC from patients as well as to autologous APC. These observations strongly suggest that the low responsiveness to PPD in childhood cancer patients results from the dysfunction of T cells, and the capacity of APC is fully preserved. In other words, it appears that the capacity of APC is not impaired by chemotherapy, neoplastic cells, or other factors. Suppressor T cells appeared not to be involved in such dysfunction of T cells.
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ISSN:0016-450X
DOI:10.20772/cancersci1959.75.12_1108