Molecular and functional significance of Ca2+-activated Cl− channels in pulmonary arterial smooth muscle

• Published in: Pulmonary circulation Vol. 5; no. 2; pp. 244 - 268
• Main Authors: Leblanc, Normand, Forrest, Abigail S., Ayon, Ramon J., Wiwchar, Michael, Angermann, Jeff E., Pritchard, Harry A. T., Singer, Cherie A., Valencik, Maria L., Britton, Fiona, Greenwood, Iain A.
• Format: Journal Article
• Language: English
• Published: London, England University of Chicago Press 01.06.2015; SAGE Publications; John Wiley & Sons, Inc
• Subjects: Agonists; Anions; anoctamin; bestrophin; calcium‐activated chloride channels; Cell membranes; Depolarization; Electric potential; Kinetics; Phosphorylation; Pulmonary arteries; Pulmonary artery; pulmonary hypertension; Receptors; Review; Review Article; Smooth muscle; TMEM16A; calcium-activated chloride channels; TMEM16A; pulmonary hypertension; bestrophin; anoctamin
• ISSN: 2045-8932; 2045-8940; 2045-8940
• DOI: 10.1086/680189

Increased peripheral resistance of small distal pulmonary arteries is a hallmark signature of pulmonary hypertension (PH) and is believed to be the consequence of enhanced vasoconstriction to agonists, thickening of the arterial wall due to remodeling, and increased thrombosis. The elevation in arte...