Dexmedetomidine and Phosphocreatine Post-treatment Provides Protection against Focal Cerebral Ischemia-reperfusion Injury in Rats

• Published in: ACTA HISTOCHEMICA ET CYTOCHEMICA Vol. 54; no. 4; pp. 105 - 113
• Main Authors: Shen, Yujun, Sun, Xiaofen, Shen, Yuxian, Kang, Fang, Li, Juan
• Format: Journal Article
• Language: English
• Published: Japan JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY 25.08.2021; Japan Science and Technology Agency
• Subjects: 4-Hydroxynonenal; Blood-brain barrier; Caspase-3; Cerebral blood flow; Cerebral infarction; dexmedetomidine; Electron microscopy; Ischemia; Magnetic resonance imaging; Malondialdehyde; Mitochondria; Neuroimaging; Neuroprotection; Oxidative stress; Phosphocreatine; post-ischemia treatment; Regular; Reperfusion; reperfusion injury; Rodents; Triphenyltetrazolium chloride; post-ischemia treatment; dexmedetomidine; reperfusion injury; phosphocreatine; neuroprotection

In this study we investigated the neuroprotective efficacy of dexmedetomidine (Dex) and phosphocreatine (PCr) alone or in combination in a rat model of focal cerebral ischemia-reperfusion injury (I/R). I/R was induced by intraluminal middle cerebral artery occlusion (MCAO) and reperfusion. Male Spra...