PROTECTIVE EFFECTS OF DL-TRYPTOPHAN ON BENZIDINE-INDUCED HEPATIC TUMOR IN MICE

This study was undertaken to evaluate the carcinogenic effect of benzidine on the urinary bladder of mice, and the effect of DL-tryptophan on the induction of bladder cancer. Benzidine plus DL-tryptophan or benzidine alone mixed with a commercial basal diet was fed to groups of ICR strain female mic...

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Published inGANN Japanese Journal of Cancer Research Vol. 71; no. 2; pp. 265 - 268
Main Authors YOSHIDA, Osamu, MIYAKAWA, Mieko
Format Journal Article
LanguageEnglish
Published Japan The Japanese Cancer Association 01.01.1980
Subjects
Animals
Benzidine
Benzidines - administration & dosage
Benzidines - antagonists & inhibitors
Benzidines - toxicity
DL-Tryptophan
Female
ICR mouse
Liver
Liver Neoplasms - chemically induced
Liver Neoplasms - prevention & control
Liver Neoplasms, Experimental - chemically induced
Liver Neoplasms, Experimental - prevention & control
Mice
Mice, Inbred ICR
Neoplasms, Experimental - chemically induced
Tryptophan - administration & dosage
Tryptophan - pharmacology
Urinary Bladder Neoplasms - chemically induced
Online AccessGet full text
ISSN0016-450X
DOI10.20772/cancersci1959.71.2_265

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Abstract This study was undertaken to evaluate the carcinogenic effect of benzidine on the urinary bladder of mice, and the effect of DL-tryptophan on the induction of bladder cancer. Benzidine plus DL-tryptophan or benzidine alone mixed with a commercial basal diet was fed to groups of ICR strain female mice for 20 weeks, after a glass bead had been inserted into the bladder. Control mice were fed the basal diet throughout the experimental period. All the surviving mice were killed 63 weeks after start of the study. Benzidine administered with or without DL-tryptophan did not induce tumors of the urinary bladder in these mice. Hepatomas developed in 34 of 41 mice (82.9%) fed benzidine and in 24 of 51 mice (47.1 %) fed benzidine with tryptophan. DL-Tryptophan counteracted the effect of benzidine and significantly reduced the development of hepatomas.
AbstractList This study was undertaken to evaluate the carcinogenic effect of benzidine on the urinary bladder of mice, and the effect of DL-tryptophan on the induction of bladder cancer. Benzidine plus DL-tryptophan or benzidine alone mixed with a commercial basal diet was fed to groups of ICR strain female mice for 20 weeks, after a glass bead had been inserted into the bladder. Control mice were fed the basal diet throughout the experimental period. All the surviving mice were killed 63 weeks after start of the study. Benzidine administered with or without DL-tryptophan did not induce tumors of the urinary bladder in these mice. Hepatomas developed in 34 of 41 mice (82.9%) fed benzidine and in 24 of 51 mice (47.1%) fed benzidine with tryptophan. DL-Tryptophan counteracted the effect of benzidine and significantly reduced the development of hepatomas.This study was undertaken to evaluate the carcinogenic effect of benzidine on the urinary bladder of mice, and the effect of DL-tryptophan on the induction of bladder cancer. Benzidine plus DL-tryptophan or benzidine alone mixed with a commercial basal diet was fed to groups of ICR strain female mice for 20 weeks, after a glass bead had been inserted into the bladder. Control mice were fed the basal diet throughout the experimental period. All the surviving mice were killed 63 weeks after start of the study. Benzidine administered with or without DL-tryptophan did not induce tumors of the urinary bladder in these mice. Hepatomas developed in 34 of 41 mice (82.9%) fed benzidine and in 24 of 51 mice (47.1%) fed benzidine with tryptophan. DL-Tryptophan counteracted the effect of benzidine and significantly reduced the development of hepatomas.
This study was undertaken to evaluate the carcinogenic effect of benzidine on the urinary bladder of mice, and the effect of DL-tryptophan on the induction of bladder cancer. Benzidine plus DL-tryptophan or benzidine alone mixed with a commercial basal diet was fed to groups of ICR strain female mice for 20 weeks, after a glass bead had been inserted into the bladder. Control mice were fed the basal diet throughout the experimental period. All the surviving mice were killed 63 weeks after start of the study. Benzidine administered with or without DL-tryptophan did not induce tumors of the urinary bladder in these mice. Hepatomas developed in 34 of 41 mice (82.9%) fed benzidine and in 24 of 51 mice (47.1 %) fed benzidine with tryptophan. DL-Tryptophan counteracted the effect of benzidine and significantly reduced the development of hepatomas.
Author MIYAKAWA, Mieko
YOSHIDA, Osamu
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3) Boyland, E., Watson, G., Nature (London), 177, 837-838 (1956).
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References_xml – reference: 12) Matsumoto, M., Hopp, M. L., Oyasu, R., Invest. Urol., 14, 206-209 (1976).
– reference: 20) Yoshida, O., Miyakawa, M., Abstr. XI Int. Cancer Congr., 3, 343 (1974).
– reference: 11) Maltry, E., Jr., "Benign and Malignant Tumors of the Urinary Bladder," pp. 194-196 (1971). Igaku Shoin, Tokyo.
– reference: 13) Miyakawa, M., Yoshida, O., Gann, 66, 437-439 (1975).
– reference: 6) Conzelman, G. M., Jr., Moulton, J. E., Flanders, L. E., III., Springer, K., Crout, D. W., J. Natl. Cancer Inst., 42, 825-836 (1969).
– reference: 8) Goldblatt, M,. W., Br., J. Ind. Med., 6, 65-81 (1949).
– reference: 7) Dunning, W. F., Curtis, M. R., Maun, M. E., Cancer Res., 10, 454-459 (1950).
– reference: 1) Arcos, J. C., Argus, M. F., "Chemical Induction of Cancer," Vol. IIB, pp. 65-84 (1974). Academic Press, New York.
– reference: 16) Radomski, J. L., Glass, E. M., Deichmann, W. B., Cancer Res., 31, 1690-1694 (1971).
– reference: 15) Quagliariello, E., Auricchis, S., Rinaldi, E., Rubino, A., Nature (London), 182, 1744 (1958).
– reference: 2) Bonser, G. M., Clayson, D. B., Jull, J. W., Pyrah, L. N. Br. J. Cancer, 6, 412-424 (1952).
– reference: 9) Hopp, M. L., Matsumoto, M., Wendell, B., Lee, C., Oyasu, R., Cancer Res., 36, 234-239 (1976).
– reference: 14) Oyasu, R., Kitajima, T., Hopp, M. L., Hirotoshi, S., Cancer Res., 32, 2027-2033 (1972).
– reference: 18) Spitz, S., Maguigan, W. H., Dobriner, K., Cancer, 3, 789-804 (1950).
– reference: 10) Hueper, W. C., "Occupational and Environmental Cancer of the Urinary System," pp. 229-237 (1969). Yale University Press, New Heaven.
– reference: 5) Conzelman, J. M., Jr., Flanders, L. E., III., Springer, K., Crout, D. W., Am. J. Vet. Res., 30, 2083-2090 (1969).
– reference: 17) Radomski, J. L., Radomski, T., MacDonald, W. E., J. Natl. Cancer Inst., 58, 1831-1834 (1977).
– reference: 4) Clayson, D. B., Lawson, T. A., Pringle, J. A. S., Br. J. Cancer, 21, 755-762 (1967).
– reference: 19) Yoshida, O., Miyakawa, M., Proc. 3rd Int. Symp. Princess Takamatsu Cancer Res. Fund, 31-39 (1973).
– reference: 3) Boyland, E., Watson, G., Nature (London), 177, 837-838 (1956).
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SubjectTerms Animals
Benzidine
Benzidines - administration & dosage
Benzidines - antagonists & inhibitors
Benzidines - toxicity
DL-Tryptophan
Female
ICR mouse
Liver
Liver Neoplasms - chemically induced
Liver Neoplasms - prevention & control
Liver Neoplasms, Experimental - chemically induced
Liver Neoplasms, Experimental - prevention & control
Mice
Mice, Inbred ICR
Neoplasms, Experimental - chemically induced
Tryptophan - administration & dosage
Tryptophan - pharmacology
Urinary Bladder Neoplasms - chemically induced
Title PROTECTIVE EFFECTS OF DL-TRYPTOPHAN ON BENZIDINE-INDUCED HEPATIC TUMOR IN MICE
URI https://www.jstage.jst.go.jp/article/cancersci1959/71/2/71_2_265/_article/-char/en
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