LncRNA‐PCAT1 targeting miR‐145‐5p promotes TLR4‐associated osteogenic differentiation of adipose‐derived stem cells

• Published in: Journal of cellular and molecular medicine Vol. 22; no. 12; pp. 6134 - 6147
• Main Authors: Yu, Lingjia, Qu, Hao, Yu, Yifeng, Li, Wenjing, Zhao, Yu, Qiu, Guixing
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.12.2018
• Subjects: Adipocytes - cytology; Adipocytes - metabolism; Bone Marrow Cells - cytology; Bone Marrow Cells - metabolism; Cell Differentiation - genetics; Gene Expression Regulation, Developmental - genetics; Humans; lncRNA‐PCAT1; Mesenchymal Stem Cells - metabolism; MicroRNAs - genetics; miR‐145‐5p; Original; Osteoblasts - metabolism; Osteogenesis - genetics; osteogenic differentiation; RNA, Long Noncoding - genetics; Signal Transduction - genetics; TLR4; Toll-Like Receptor 4 - genetics; Toll‐like receptor signalling pathway; lncRNA-PCAT1; Toll-like receptor signalling pathway; TLR4; osteogenic differentiation; miR-145-5p

This study was aimed to explore the differential expression of long noncoding RNAs (lncRNA)‐PCAT1, miR‐145‐5p and TLR4 in osteogenic differentiation via the Toll‐like receptor (TLR) signalling pathway and consequently determine the potential molecular mechanism. The mRNAs and pathways related to the...