Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects - Klumpers, Linda E.; Fridberg, Marianne; Kam, Marieke L.; Little, Paul B.; Jensen, Niels Ole; Kleinloog, Hendrik D.; Elling, Christian E.; Gerven, Joop M. A. (British journal of clinical pharmacology, 2013)
Keywords: Adolescent; Adult; Blood Pressure - drug effects; Cannabinoid Receptor Agonists - pharmacology; Cannabinoid Receptor Antagonists - administration & dosage; Cannabinoid Receptor Antagonists - adverse effects; Cannabinoid Receptor Antagonists - pharmacokinetics; Cannabinoid Receptor Antagonists - pharmacology; cannabinoid receptor type 1 antagonist; Clinical Trials; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Dronabinol - pharmacology; Healthy Volunteers; Heart Rate - drug effects; Humans; Male; Middle Aged; Models, Biological; peripheral CB1 antagonist; Peripheral Nervous System - drug effects; pharmacokinetics; Piperidines - administration & dosage; Piperidines - adverse effects; Piperidines - pharmacokinetics; Piperidines - pharmacology; PK−PD; Pyrazoles - administration & dosage; Pyrazoles - adverse effects; Pyrazoles - pharmacokinetics; Pyrazoles - pharmacology; Receptor, Cannabinoid, CB1 - agonists; Receptor, Cannabinoid, CB1 - antagonists & inhibitors; rimonabant; TM38837; Young Adult; pharmacokinetics; cannabinoid receptor type 1 antagonist; PK−PD; rimonabant; peripheral CB1 antagonist; TM38837