Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP1 and PP2A

• Published in: FEBS letters Vol. 593; no. 20; pp. 2908 - 2924
• Main Authors: Holder, James, Poser, Elena, Barr, Francis A.
• Format: Journal Article
• Language: English
• Published: England 01.10.2019
• Subjects: abscission; anaphase; Anaphase-Promoting Complex-Cyclosome - genetics; Anaphase-Promoting Complex-Cyclosome - metabolism; Antigens, CD - genetics; Antigens, CD - metabolism; Aurora Kinase A - genetics; Aurora Kinase A - metabolism; Cadherins - genetics; Cadherins - metabolism; Cdc20 Proteins - genetics; Cdc20 Proteins - metabolism; cell cycle; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; chromatids; Cyclin B - genetics; Cyclin B - metabolism; cyclins; cytokinesis; Cytokinesis - genetics; Gene Expression Regulation; Humans; kinase; M Phase Cell Cycle Checkpoints; mitosis; mitotic exit; phosphatase; phosphotransferases (kinases); Polo-Like Kinase 1; Protein Phosphatase 1 - genetics; Protein Phosphatase 1 - metabolism; Protein Phosphatase 2 - genetics; Protein Phosphatase 2 - metabolism; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Proteolysis; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Securin - genetics; Securin - metabolism; Signal Transduction; Spatio-Temporal Analysis; threonine; kinase; mitotic exit; phosphatase; mitosis; cell cycle; proteolysis

Here, we will review the evidence showing that mitotic exit is initiated by regulated proteolysis and then driven by the PPP family of phosphoserine/threonine phosphatases. Rapid APC/CCDC20 and ubiquitin‐dependent proteolysis of cyclin B and securin initiates sister chromatid separation, the first s...