Plasma NOx Concentrations in Glucose Intolerance and Type 2 Diabetes A Case-control Study in a Vietnamese Population

• Published in: Journal of Atherosclerosis and Thrombosis Vol. 18; no. 4; pp. 305 - 311
• Main Authors: Binh, Phan Nguyen Thanh, Abe, Yasunori, Tien, Pham Gia, Le Nguyen Trung Duc Son, Hanh, Tran Thi Minh, Diep, Do Thi Ngoc, Qui, Le Thi Kim, Kawano, Mikihiko, Maruyama, Chizuko
• Format: Journal Article
• Language: English
• Published: Japan Japan Atherosclerosis Society 01.01.2011
• Subjects: Adiposity; Adult; Aged; Asian Continental Ancestry Group; Biomarkers - blood; Case-Control Studies; Case-control study; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - epidemiology; Glucose Intolerance - blood; Glucose Intolerance - epidemiology; Humans; Insulin Resistance; Middle Aged; Nitrogen Oxides - blood; Predictive Value of Tests; Vietnam - epidemiology; Vietnam
• DOI: 10.5551/jat.7393
• ISSN: 1340-3478

Aim: The Vietnamese develop type 2 diabetes (T2D) and metabolic syndrome (MS) at a lower BMI than other ethnicities. Thus, biomarkers that identify subjects at an increased risk of T2D independently of obesity are being sought. Recent studies show that circulating NO metabolites (NOx) are increased in T2D. We investigated whether plasma NOx levels predict insulin resistance and glucose intolerance before the development of T2D, independently of obesity. Methods: The current study was derived from a population-based study in HCMC, Vietnam, which was designed to investigate the prevalence of MS and T2D in a population aged 30-69 years. Four hundred and twenty-two subjects were recruited from the study and were stratified into 4 age- and gender-matched groups according to a glucose tolerance test {normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and T2D}. Results: Plasma NOx concentrations were significantly increased in T2D but not in IFG or IGT compared with NGT. Multiregression analysis showed that plasma NOx levels were inversely correlated with BMI in T2D whereas no association was found between plasma NOx levels and BMI in non-diabetic subjects. Moreover, there was no correlation between plasma NOx levels and homeostasis model assessment-insulin resistance (HOMA-IR) in both diabetic and non-diabetic subjects. Conclusion: Plasma NOx levels did not predict glucose intolerance or insulin resistance before the development of T2D and the increase in plasma NOx levels in T2D was not caused by adiposity. Thus, plasma NOx is not a useful marker for the prediction of high-risk subjects for T2D among Vietnamese.