Factors influencing biased agonism in recombinant cells expressing the human α1A‐adrenoceptor

• Published in: British journal of pharmacology Vol. 174; no. 14; pp. 2318 - 2333
• Main Authors: Silva Junior, Edilson Dantas, Sato, Masaaki, Merlin, Jon, Broxton, Natalie, Hutchinson, Dana S, Ventura, Sabatino, Evans, Bronwyn A, Summers, Roger J
• Format: Journal Article
• Language: English
• Published: Hoboken John Wiley and Sons Inc 01.07.2017
• Subjects: Research Paper; Research Papers

Background and Purpose Agonists acting at GPCRs promote biased signalling via Gα or Gβγ subunits, GPCR kinases and β‐arrestins. Since the demonstration of biased agonism has implications for drug discovery, it is essential to consider confounding factors contributing to bias. We have examined bias a...