Quantitative Prediction of the Effect of CYP3A Inhibitors and Inducers on Venetoclax Pharmacokinetics Using a Physiologically Based Pharmacokinetic Model - Freise, Kevin J; Shebley, Mohamad; Salem, Ahmed Hamed (Journal of clinical pharmacology, 2017)
Keywords: Antineoplastic Agents - blood; Antineoplastic Agents - pharmacokinetics; Bridged Bicyclo Compounds, Heterocyclic - blood; Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics; Cytochrome P-450 CYP3A Inducers - pharmacology; Cytochrome P-450 CYP3A Inhibitors - pharmacology; Drug Interactions; Female; Humans; Models, Biological; Sulfonamides - blood; Sulfonamides - pharmacokinetics; ABT-199/GDC-0199; PBPK; BCL-2; CYP3A; venetoclax; drug-drug interaction