In Vitro Assessment of 36 CYP2C9 Allelic Isoforms Found in the Chinese Population on the Metabolism of Glimepiride

• Published in: Basic & clinical pharmacology & toxicology Vol. 114; no. 4; pp. 305 - 310
• Main Authors: Dai, Da‐Peng, Wang, Shuang‐Hu, Geng, Pei‐Wu, Hu, Guo‐Xin, Cai, Jian‐Ping
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.04.2014; Wiley Subscription Services, Inc
• Subjects: Alleles; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; Asian Continental Ancestry Group - genetics; Biological and medical sciences; China; Cytochrome P-450 CYP2C9; General and cellular metabolism. Vitamins; Genotype; Humans; Hydroxylation; Hypoglycemic Agents - pharmacology; Medical sciences; Microsomes - metabolism; Mutation; Pharmacology. Drug treatments; Polymorphism, Genetic; Protein Isoforms - genetics; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Sulfonylurea Compounds - pharmacology; Tandem Mass Spectrometry; China; Human; Evaluation; Glimepiride; Molecular form; Enzyme; Isozyme; Cytochrome P450; Metabolism; In vitro; Hypoglycemic agent; Sulfonamides; Sulfonylureas; Chinese; Pharmacokinetics; CYP2C9 gene

Of the 57 reported CYP2C9 alleles, to date, 36 of them have been identified in the Chinese population. The aim of this study was to assess the catalytic characteristics of these allelic isoforms and their effects on the metabolism of glimepiride in vitro. Baculovirus‐mediated expressing system was u...