Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin‐dependent kinases and the phosphoinositide 3‐kinase/AKT signaling cascade

• Published in: Cancer science Vol. 103; no. 9; pp. 1640 - 1650
• Main Authors: Wei, Tong‐You W., Juan, Chi‐Chang, Hisa, Jiun‐Yi, Su, Li‐Jen, Lee, Yuan‐Chii G., Chou, Hsiang‐Yun, Chen, Jo‐Mei M., Wu, Yu‐Chung, Chiu, Shao‐Chih, Hsu, Chung‐Ping, Liu, Kuo‐Lin, Yu, Chang‐Tze R.
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.09.2012
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Animals; c-Jun amino-terminal kinase; c-Jun protein; Cell adhesion; Cell cycle; Cell density; Cell Line, Tumor; Cell proliferation; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; cyclin D1; Cyclin-dependent kinase; Cyclin-Dependent Kinases - metabolism; Cyclins; Data processing; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Mice; Mice, Nude; Oncogene Proteins - genetics; Oncogene Proteins - metabolism; Original; Phosphatidylinositol 3-Kinases - metabolism; phosphoinositides; protein arginine methyltransferase; Protein-Arginine N-Methyltransferases - genetics; Protein-Arginine N-Methyltransferases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Retinoblastoma protein; Signal Transduction; Statistical analysis; Transcription factors; Tumor cell lines; Tumorigenesis; Western blotting

Increasing evidence suggests that PRMT5, a protein arginine methyltransferase, is involved in tumorigenesis. However, no systematic research has demonstrated the cell‐transforming activity of PRMT5. We investigated the involvement of PRMT5 in tumor formation. First, we showed that PRMT5 was associat...