The Methyltransferase-Like Domain of Chikungunya Virus nsP2 Inhibits the Interferon Response by Promoting the Nuclear Export of STAT1

• Published in: Journal of virology Vol. 92; no. 17
• Main Authors: Göertz, Giel P, McNally, Kristin L, Robertson, Shelly J, Best, Sonja M, Pijlman, Gorben P, Fros, Jelke J
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.09.2018
• Subjects: Cell Line; Chikungunya virus - enzymology; Chikungunya virus - genetics; Chikungunya virus - physiology; Computer Simulation; Cysteine Endopeptidases - genetics; Cysteine Endopeptidases - metabolism; HEK293 Cells; Host-Pathogen Interactions - genetics; Host-Pathogen Interactions - immunology; Humans; Immunity, Innate; Immunoprecipitation; Interferon Type I - antagonists & inhibitors; Interferon Type I - genetics; Interferon Type I - immunology; Methyltransferases - metabolism; Mutation; Signal Transduction - genetics; Signal Transduction - immunology; STAT1 Transcription Factor - genetics; Virus Replication; Virus-Cell Interactions; nonstructural protein 2; STAT signaling; interferons; alphavirus; innate immunity; chikungunya

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has evolved effective mechanisms to counteract the type I interferon (IFN) response. Upon recognition of the virus, cells secrete IFNs, which signal through transmembrane receptors (IFNAR) to phosphorylate STAT proteins (pSTAT). pSTAT dim...