Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells

• Published in: Cancer science Vol. 108; no. 9; pp. 1803 - 1810
• Main Authors: Matsumoto, Akihiro, Takahashi, Yuki, Nishikawa, Makiya, Sano, Kohei, Morishita, Masaki, Charoenviriyakul, Chonlada, Saji, Hideo, Takakura, Yoshinobu
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.09.2017
• Subjects: Aniline Compounds - pharmacology; Animals; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis Regulatory Proteins - metabolism; Benzylidene Compounds - pharmacology; Biodistribution; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; exosomes; Exosomes - metabolism; Male; melanoma; Melanoma, Experimental - metabolism; Melanoma, Experimental - pathology; Mice, Inbred C57BL; Neoplasm Transplantation; Original; proliferation; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; Tumor Burden; uptake; melanoma; proliferation; uptake; Biodistribution; exosomes

Exosomes are extracellular vesicles released by various cell types and play roles in cell–cell communication. Several studies indicate that cancer cell‐derived exosomes play important pathophysiological roles in tumor progression. Biodistribution of cancer cell‐derived exosomes in tumor tissue is an...