Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a Thyroid hormone-regulated gene in specific brain regions

• Published in: Journal of neurochemistry Vol. 73; no. 6; pp. 2240 - 2249
• Main Authors: ALVAREZ-DOLADO, M, GONZALEZ-MORENO, M, VALENCIA, A, ZENKE, M, BERNAL, J, MUNOZ, A
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.12.1999
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Biological and medical sciences; Brain - metabolism; Endocrinopathies; Fungal Proteins - chemistry; Gene Expression Profiling; Gene Expression Regulation, Developmental - drug effects; Genes; Humans; Hypothyroidism - chemically induced; Hypothyroidism - metabolism; In Situ Hybridization; Medical sciences; Membrane Proteins - chemistry; Membrane Proteins - genetics; Membrane Proteins - isolation & purification; Membrane Proteins - physiology; Membrane Transport Proteins; Mitochondria - metabolism; Mitochondrial Membrane Transport Proteins; mitochondrial precursor protein; Mitochondrial Proteins; Molecular Sequence Data; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Rats; Rats, Wistar; RNA, Messenger - biosynthesis; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Subtraction Technique; Thyroid Gland - physiology; Thyroid. Thyroid axis (diseases); Thyroxine - pharmacology; Endocrinopathy; Rat; Rodentia; Thyroid diseases; Homology; Corpus striatum; Identification; Hypothyroidism; Vertebrata; Experimental disease; Mammalia; Gene; Animal; Thyroid hormone

Thyroid hormone is an important regulator of mammalian brain maturation. By differential display PCR, we isolated a cDNA clone (S2) that is specifically up-regulated in the striatum of neonatal hypothyroid rats. S2 was identified as KIAA0719, the first human gene distantly homologous to the fungal T...