Molecular Cell Biology of Apoptosis and Necroptosis in Cancer

• Published in: Advances in experimental medicine and biology Vol. 930; p. 1
• Main Authors: Dillon, Christopher P, Green, Douglas R
• Format: Journal Article
• Language: English
• Published: United States 01.01.2016
• Subjects: Animals; Apoptosis - physiology; Apoptosis Regulatory Proteins - physiology; Caspases - physiology; Cell Death - physiology; Cytokines - physiology; Humans; Inflammasomes - physiology; Mice; Mice, Knockout; Mitochondria - physiology; Molecular Targeted Therapy - methods; Necrosis; Neoplasm Proteins - physiology; Neoplasms - drug therapy; Neoplasms - immunology; Neoplasms - metabolism; Neoplasms - pathology; Receptor-Interacting Protein Serine-Threonine Kinases - deficiency; Receptor-Interacting Protein Serine-Threonine Kinases - physiology; Receptors, Death Domain - physiology; Signal Transduction; BCL-2; RIPK3; Cell death; Necroptosis; Immunogenic; Inflammation; Caspases; Apoptosis; Cancer

Cell death is a major mechanism to eliminate cells in which DNA is damaged, organelles are stressed, or oncogenes are overexpressed, all events that would otherwise predispose cells to oncogenic transformation. The pathways that initiate and execute cell death are complex, genetically encoded, and s...