Neutrophil CD64 expression as a diagnostic marker for local infection and crystal-induced arthritis
The usefulness of neutrophil CD64 expression was examined in diagnosing local infection, including soft tissue, bone, and joint infections. Among 99 patients suspected of local infection, 31 were confirmed and 68 patients were not. The CD64 level of patients with local infection was significantly hi...
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| Published in | Modern rheumatology Vol. 20; no. 6; pp. 573 - 579 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
Springer Japan
01.12.2010
Informa Healthcare |
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| Abstract | The usefulness of neutrophil CD64 expression was examined in diagnosing local infection, including soft tissue, bone, and joint infections. Among 99 patients suspected of local infection, 31 were confirmed and 68 patients were not. The CD64 level of patients with local infection was significantly higher than in those without infection [4,193 ± 1,132 vs. 1,017 ± 59 molecules/cell (mean ± standard deviation);
p
< 0.001]. The area under the curve of CD64 calculated by receiver operating characteristic curve analysis was larger than that of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), or white blood cell (WBC) count. In addition, CD64 levels of patients with crystal-induced arthritis remained within cutoff value (2,000 molecules/cell). These data suggest that measuring CD64 expression can be a useful diagnostic marker for local musculoskeletal infection and crystal-induced arthritis. |
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| AbstractList | The usefulness of neutrophil CD64 expression was examined in diagnosing local infection, including soft tissue, bone, and joint infections. Among 99 patients suspected of local infection, 31 were confirmed and 68 patients were not. The CD64 level of patients with local infection was significantly higher than in those without infection [4,193 ± 1,132 vs. 1,017 ± 59 molecules/cell (mean ± standard deviation);
p
< 0.001]. The area under the curve of CD64 calculated by receiver operating characteristic curve analysis was larger than that of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), or white blood cell (WBC) count. In addition, CD64 levels of patients with crystal-induced arthritis remained within cutoff value (2,000 molecules/cell). These data suggest that measuring CD64 expression can be a useful diagnostic marker for local musculoskeletal infection and crystal-induced arthritis. The usefulness of neutrophil CD64 expression was examined in diagnosing local infection, including soft tissue, bone, and joint infections. Among 99 patients suspected of local infection, 31 were confirmed and 68 patients were not. The CD64 level of patients with local infection was significantly higher than in those without infection [4,193 plus or minus 1,132 vs. 1,017 plus or minus 59 molecules/cell (mean plus or minus standard deviation); p<0.001]. The area under the curve of CD64 calculated by receiver operating characteristic curve analysis was larger than that of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), or white blood cell (WBC) count. In addition, CD64 levels of patients with crystal-induced arthritis remained within cutoff value (2,000 molecules/cell). These data suggest that measuring CD64 expression can be a useful diagnostic marker for local musculoskeletal infection and crystal-induced arthritis. The usefulness of neutrophil CD64 expression was examined in diagnosing local infection, including soft tissue, bone, and joint infections. Among 99 patients suspected of local infection, 31 were confirmed and 68 patients were not. The CD64 level of patients with local infection was significantly higher than in those without infection [4,193 ± 1,132 vs. 1,017 ± 59 molecules/cell (mean ± standard deviation); p < 0.001]. The area under the curve of CD64 calculated by receiver operating characteristic curve analysis was larger than that of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), or white blood cell (WBC) count. In addition, CD64 levels of patients with crystal-induced arthritis remained within cutoff value (2,000 molecules/cell). These data suggest that measuring CD64 expression can be a useful diagnostic marker for local musculoskeletal infection and crystal-induced arthritis. The usefulness of neutrophil CD64 expression was examined in diagnosing local infection, including soft tissue, bone, and joint infections. Among 99 patients suspected of local infection, 31 were confirmed and 68 patients were not. The CD64 level of patients with local infection was significantly higher than in those without infection [4,193 ± 1,132 vs. 1,017 ± 59 molecules/cell (mean ± standard deviation); p < 0.001]. The area under the curve of CD64 calculated by receiver operating characteristic curve analysis was larger than that of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), or white blood cell (WBC) count. In addition, CD64 levels of patients with crystal-induced arthritis remained within cutoff value (2,000 molecules/cell). These data suggest that measuring CD64 expression can be a useful diagnostic marker for local musculoskeletal infection and crystal-induced arthritis.[PUBLICATION ABSTRACT] |
| Author | Komiya, Akiko Hasegawa, Jun Omata, Yasunori Matsui, Toshihiro Mori, Toshihito Tanaka, Sakae Yamamoto, Seizo Tohma, Shigeto Miyazaki, Tsuyoshi Doi, Toru Nishino, Jinju Katoh, Narutaka Tokimura, Fumiaki Matsushita, Takashi Nishimura, Keita |
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| Cites_doi | 10.1016/j.jemermed.2006.07.019 10.1302/0301-620X.91B9.22051 10.1093/rheumatology/keg297 10.1002/art.10524 10.1034/j.1399-3038.2002.01064.x 10.1097/00024382-200116020-00003 10.1016/S0161-5890(98)00079-0 10.1136/ard.61.6.522 10.1203/00006450-200203000-00006 10.1046/j.1365-2567.1997.00249.x 10.1016/S0161-5890(98)00069-8 10.1203/00006450-199906000-00016 10.1016/0140-6736(93)90277-N 10.1007/BF01740811 |
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| Keywords | CD64 Arthritis Local infection Gout Pseudogout |
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| References_xml | – volume: 32 start-page: 23 year: 2007 end-page: 26 ident: CR7 article-title: Does the presence of crystal arthritis rule out septic arthritis? publication-title: J Emerg Med doi: 10.1016/j.jemermed.2006.07.019 contributor: fullname: Edlow – volume: 57 start-page: 455 year: 1995 end-page: 461 ident: CR3 article-title: Mature polymorphonuclear leukocytes express high-affinity receptors for IgG (Fc gamma RI) after stimulation with granulocyte colony-stimulating factor (G-CSF) publication-title: J Leukoc Biol contributor: fullname: Ely – volume: 91 start-page: 1237 year: 2009 end-page: 1242 ident: CR17 article-title: Neutrophil CD64 expression in the diagnosis of local musculoskeletal infection and the impact of antibiotics publication-title: J Bone Joint Surg Br doi: 10.1302/0301-620X.91B9.22051 contributor: fullname: Tohma – volume: 42 start-page: 1062 year: 2003 end-page: 1066 ident: CR6 article-title: Concomitant septic and gouty arthritis––an analysis of 30 cases 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| SubjectTerms | Biomarkers Gene expression Infections Medicine Medicine & Public Health Original Article Orthopedics Rheumatoid arthritis Rheumatology |
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| Title | Neutrophil CD64 expression as a diagnostic marker for local infection and crystal-induced arthritis |
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