Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6

• Published in: Science (American Association for the Advancement of Science) Vol. 334; no. 6058; pp. 941 - 948
• Main Authors: Klinge, Sebastian, Voigts-Hoffmann, Felix, Leibundgut, Marc, Arpagaus, Sofia, Ban, Nenad
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 18.11.2011; The American Association for the Advancement of Science
• Subjects: active sites; Anti-Bacterial Agents - metabolism; Antibiotics; Base Sequence; Binding Sites; Biological and medical sciences; Crystal structure; Crystalline structure; Crystallization; Crystallography, X-Ray; cycloheximide; Cycloheximide - metabolism; Eukaryotes; Eukaryotic Initiation Factors - chemistry; Eukaryotic Initiation Factors - metabolism; Fundamental and applied biological sciences. Psychology; Models, Molecular; Molecular and cellular biology; Molecular biophysics; Molecular genetics; Molecular Sequence Data; Nucleic Acid Conformation; Peptide Chain Initiation, Translational; polypeptides; Protein Conformation; Protein Structure, Secondary; protein subunits; Protein synthesis; Proteins; Protozoan Proteins - chemistry; Protozoan Proteins - metabolism; RESEARCH ARTICLE; Ribonucleic acid; Ribosomal proteins; Ribosomal Proteins - chemistry; Ribosomal Proteins - metabolism; Ribosome Subunits, Large, Eukaryotic - chemistry; Ribosome Subunits, Large, Eukaryotic - metabolism; Ribosome Subunits, Large, Eukaryotic - ultrastructure; Ribosomes; RNA; RNA, Protozoan - chemistry; RNA, Protozoan - metabolism; RNA, Ribosomal - chemistry; RNA, Ribosomal - metabolism; RNA, Ribosomal, 5.8S - chemistry; RNA, Ribosomal, 5.8S - metabolism; Structure in molecular biology; Tetrahymena thermophila; Tetrahymena thermophila - chemistry; Tetrahymena thermophila - metabolism; Transfer RNA; Translation. Translation factors. Protein processing; Tunnels; Yeasts; Eukaryote; Ribosome; Subunit; Initiation; Crystalline structure

Protein synthesis in all organisms is catalyzed by ribosomes. In comparison to their prokaryotic counterparts, eukaryotic ribosomes are considerably larger and are subject to more complex regulation. The large ribosomal subunit (60S) catalyzes peptide bond formation and contains the nascent polypept...