Inactivation of SARS-CoV-2 by povidone-iodine products : implications for effective mouth rinsing and gargling

[Abstract] Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is transmitted mainly via droplets and contact. The implementation of infection control measures is important to reduce the number of COVID-19 cases. Thus, the ability...

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Published inThe Japanese Journal of Veterinary Research Vol. 69; no. 3; pp. 183 - 187
Main Authors Hiroaki Kariwa, Hirofumi Sawa, Shintaro Kobayashi
Format Journal Article
LanguageEnglish
Published Faculty of Veterinary Medicine, Hokkaido University 01.08.2021
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Abstract [Abstract] Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is transmitted mainly via droplets and contact. The implementation of infection control measures is important to reduce the number of COVID-19 cases. Thus, the ability of several povidone-iodine (PVP-I) products to inactivate SARS-CoV-2 was evaluated based on their in vitro inactivation efficacy. PVP-I solutions such as Isodine Gargle(R) (ethical and consumer products), Isodine Gargle C(R), and Isodine Nodo Fresh(R) for 30 or 60 s decreased the viral infectivity level from 2-4 × 106 TCID50/ml to below the detectable level (> 99.9% reduction). Our results indicate that the use of Isodine(R) mouthwash and gargle products is an effective infection control measure against SARS-CoV-2.
AbstractList [Abstract] Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is transmitted mainly via droplets and contact. The implementation of infection control measures is important to reduce the number of COVID-19 cases. Thus, the ability of several povidone-iodine (PVP-I) products to inactivate SARS-CoV-2 was evaluated based on their in vitro inactivation efficacy. PVP-I solutions such as Isodine Gargle(R) (ethical and consumer products), Isodine Gargle C(R), and Isodine Nodo Fresh(R) for 30 or 60 s decreased the viral infectivity level from 2-4 × 106 TCID50/ml to below the detectable level (> 99.9% reduction). Our results indicate that the use of Isodine(R) mouthwash and gargle products is an effective infection control measure against SARS-CoV-2.
Author Hirofumi Sawa
Shintaro Kobayashi
Hiroaki Kariwa
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CorporateAuthor Laboratory of Public Health
Department of Preventive Veterinary Medicine
Hokkaido University
Division of Molecular Pathobiology
Faculty of Veterinary Medicine
Research Center for Zoonosis Control
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DOI 10.14943/jjvr.69.3.183
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Snippet [Abstract] Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is transmitted mainly via...
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Title Inactivation of SARS-CoV-2 by povidone-iodine products : implications for effective mouth rinsing and gargling
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